In addition, the study population includes more than 40% of patients with type 2 diabetes (T2DM), allowing Inventiva to conduct the planned subanalyses in this key patient group, where lanifibranor as an
insulin sensitizer should be particularly beneficial.
M2 PHARMA-January 4, 2019-US Merck Exercises Option for NGM Bio's Investigational
Insulin Sensitizer, NGM313, for the Treatment of NASH and Type 2 Diabetes
"The in vitro evidence for CB4211 acting as an
insulin sensitizer is consistent with our prior preclinical observations in vivo...We believe CB4211 affects a foundational event in the etiology of NASH and potentially other metabolic diseases.
Metformin, Vitamin E,
insulin sensitizer, anti-fibrotic are also helpful.
Weighted effects of bromocriptine treatment on glucose homeostasis during hyperglycemic versus euglycemic clamp conditions in insulin resistant hamsters: Bromocriptine as a unique postprandial
insulin sensitizer. J Diabetes Metab.
[16] Metformin a antidiabetic drug which is known as
insulin sensitizer, which causes increase in glucose uptake and utilization by target tissues, also known to cause decrease IR.
DHEA has also been shown to be an
insulin sensitizer and to help protect against advanced glycation end-product formation.
MitoNEET (mitochondrial Asn-Glu-Glu-Thr), an iron-sulfur- (Fe-S-) containing mitochondrial outer membrane protein that is involved in transferring the Fe-S clusters to the cytosolic aconitase [36], had been identified by several research groups as a binding target of the
insulin sensitizer pioglitazone [37-39].
A newer usage of Ashwagandha root is as an
insulin sensitizer [8].
Anti-hyperglycemic and
insulin sensitizer effects of turmeric and its principle constituent curcumin.
Review of literature did not reveal any study that had evaluated the antidiabetic potential of combined pomegranate peel with
insulin sensitizer drug rosiglitazone.
Myo-inositol in polycystic ovarian syndrome supplement acts as a natural
insulin sensitizer in PCOS patients.