insulin sensitivity


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insulin sensitivity

The systemic responsiveness to glucose, which can be measured by
1. The insulin sensitivity index–measures the ability of endogenous insulin to ↓ glucose in extracellular fluids by inhibiting glucose release from the liver and stimulating the peripheral consumption of glucose, and.
2. The glucose-clamp technique, which measures the effect of changes in insulin concentration on glucose clearance–glucose uptake rate divided by plasma glucose concentration per unit of body surface area.
References in periodicals archive ?
Using quantitative nuclear imaging, they were able to analyze glucose uptake and insulin sensitivity in separate organs.
One study that recruited people with vitamin D deficiency and diabetes concluded that vitamin D supplements did not improve insulin sensitivity. Another paper reached similar conclusions, and another concluded: "Replenishment with a large dose of vitamin D-3 to [people] with [type 2 diabetes] and vitamin D deficiency did not change insulin sensitivity or insulin secretion." Other researchers came to similar conclusions.
The mechanism by which metformin increases insulin sensitivity --the reaction of muscle, liver and fat cells to the presence of insulin --is not well understood.
Other recent studies have shown a clear relationship between vitamin D and glycemic control, suggesting that vitamin D increases insulin sensitivity and improves pancreatic beta-cell function.
According to the study, short-duration bouts of exercise to exhaustion are just as effective in improving insulin sensitivity (how sensitive the body is to the effects of the hormone, insulin) as longer duration (45 minutes) resistance exercise sessions.
According to researchers people with low insulin sensitivity do not respond to insulin resulting in an increase in blood sugars levels, leading to the development of Type-2 diabetes.
Insulin sensitivity improved the most in the group that did moderate-intensity exercise: the equivalent of walking about 12 miles a week at a brisk pace.
Noting that shift workers, who experience circadian misalignment, have an increased risk of type 2 diabetes, Jingyi Qian, Ph.D., from Brigham and Women's Hospital in Boston, and colleagues examined the separate and relative impacts of the circadian system, behavioral/environmental cycles, and their interaction (circadian misalignment) on insulin sensitivity and ?-cell function.
The glucose clamp is a method for quantifying insulin absorption in order to measure a patient's insulin sensitivity and how well a patient metabolizes glucose.
The two exceptions were fibrosis and insulin sensitivity of adipose tissue.

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