insulin receptor substrate-1

insulin receptor substrate-1

a cytoplasmic protein that is a direct substrate of the activated insulin receptor kinase. Insulin exposure results in its rapid phosphorylation at multiple tyrosine residues. Its phosphorylated sites associate with high affinity to certain cellular proteins. IRS-1 thus acts as an adaptor molecule that links the receptor kinase to various cellular activities regulated by insulin. IRS-1 is also phosphorylated after stimulation by insulinlike growth factor-1 and several interleukins.

in·su·lin re·cep·tor sub·strate-1

(IRS-1) (in'sŭ-lin rĕ-sep'tŏr sŭb'strāt)
A cytoplasmic protein that is a direct substrate of activated insulin receptor kinase. Insulin exposure results in its rapid phosphorylation at multiple tyrosine residues. Its phosphorylated sites associate with high affinity to certain cellular proteins. IRS-1 thus acts as an adaptor molecule that links the receptor kinase to various cellular activities regulated by insulin. IRS-1 is also phosphorylated after stimulation by insulinlike growth factor-1 and several interleukins.
References in periodicals archive ?
Moreover, CPEC and its two triterpenoids not only enhanced glucose uptake in an insulin-independent manner, but also restored insulin-mediated protein kinase B (Akt) phosphorylation by reducing the activation of IKK[beta] and regulating insulin receptor substrate-1 (IRS-1) serine/tyrosine phosphorylation.
In fact, the insulin receptor substrate-1 Gly972Arg variant is widely studied in terms of its relationship to diabetes mellitus.
With further validation in larger scale clinical studies, insulin receptor substrate-1 inhibitors may prove to be a novel localized therapy for psoriasis, which can be used in conjunction with systemic treatments," analysts conclude.
These effects were associated with significant reduction in IGF-I secretion; inhibition of IGF-I-induced cell cycle progression and insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation, along with an increase in sub-G1 peak by apigenin.
Muscular Insulin receptor, Insulin receptors phosphorylation, insulin receptor substrate-1, serine/thereonine kinase.
In tissue from people with Alzheimer's disease and mild cognitive impairment (MCI), researchers found that changes to a protein called insulin receptor substrate-1 (IRS-1 pS636/639 and pS616) in brain cells were linked to the severity of memory impairments regardless of age, sex, diabetes history, or apolipoprotein E (APOE) gene status.
Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.
The core genes up-regulated in the pathways include TLR5, ROCK2, CD14, and YWHAZ, a gene encoding a member of the 14-3-3 family of proteins reported to interact with insulin receptor substrate-1 and thereby regulating insulin signaling.
Based on experiments conducted to date, TRIOLEX appears to act independently of the PPAR-gamma pathway and down regulates proinflammatory kinases JNK, IKK and p38, which have been associated with impairment of the insulin receptor substrate-1 protein (IRS-1) function, an important cellular mediator of insulin signaling, ultimately causing inappropriate insulin action.
2000) have stated that DEX induced overexpression of the P13K subunit p85alpha, competes with the complete P13K heterodimer for binding at insulin receptor substrate-1, inhibiting P13K activation.
Leading academic researchers have linked inflammation and type-2 diabetes, reporting that the chronic stimulation of the inflammatory kinases JNK and IKK can impair insulin signaling by inhibiting the biological function of insulin receptor substrate-1 (IRS-1), a protein that acts as a major mediator of insulin action in target cells.
Insulin receptor substrate-1 (IRS1) is a well-characterised intracellular substrate for insulin receptor tyrosine kinases containing Src homology 2 (SH2) domains, e.

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