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by angiotensin II," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Kunjara et al., "Insulin resistance in human preeclamptic placenta is mediated by serine phosphorylation of insulin receptor substrate-1
and -2," The Journal of Clinical Endocrinology and Metabolism, vol.
Steinle, "Silencing of insulin receptor substrate-1
increases cell death in retinal Muller cells," Molecular Vision, vol.
The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1
and phosphorylation of Ser307.
Baserga, "The insulin receptor substrate-1
: a biomarker for cancer?" Experimental Cell Research, vol 315, no.
Moreover, [ACE2.sup.-/y] mice presented a significant decrease in proteins involved in glycolysis, such as insulin receptor substrate-1
(aIRS-1), phosphatidyl inositol-3 kinase (PI3-K), and AKT compared to WT (Figures 5(c)-5(e)).
Tanti, "Interleukin-1^-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1
expression," Endocrinology, vol.
We studied glucose transporter-4 (GLUT-4) insulin receptor substrate-1
(IRS-1), Insulin receptor (IR), Phosphoenolpyrovate carboxykinase (PEPCK), Sterol regulatory element binding protein-1c (SREBP-1c), Fatty acid synthase (FAS), Peroxisome proliferator-activated receptor-a (PPAR-a), Peroxisome proliferator-activated receptor-g (PPAR-g) and tumor necrosis factor-a (TNF-a) in hepatic, skeletal muscle and adipose tissue.
Moreover, CPEC and its two triterpenoids not only enhanced glucose uptake in an insulin-independent manner, but also restored insulin-mediated protein kinase B (Akt) phosphorylation by reducing the activation of IKK[beta] and regulating insulin receptor substrate-1
(IRS-1) serine/tyrosine phosphorylation.
C-reactive protein induces phosphorylation of insulin receptor substrate-1
on Ser307 and Ser612 in L6 myocytes thereby impairing the insulin signalling pathway that promotes glucose transport.
In fact, the insulin receptor substrate-1
Gly972Arg variant is widely studied in terms of its relationship to diabetes mellitus.
 have shown that tyrosine nitration of the insulin receptor substrate-1
reduces insulin stimulated glucose uptake.