insulin receptor substrate-1

insulin receptor substrate-1

a cytoplasmic protein that is a direct substrate of the activated insulin receptor kinase. Insulin exposure results in its rapid phosphorylation at multiple tyrosine residues. Its phosphorylated sites associate with high affinity to certain cellular proteins. IRS-1 thus acts as an adaptor molecule that links the receptor kinase to various cellular activities regulated by insulin. IRS-1 is also phosphorylated after stimulation by insulinlike growth factor-1 and several interleukins.

in·su·lin re·cep·tor sub·strate-1

(IRS-1) (in'sŭ-lin rĕ-sep'tŏr sŭb'strāt)
A cytoplasmic protein that is a direct substrate of activated insulin receptor kinase. Insulin exposure results in its rapid phosphorylation at multiple tyrosine residues. Its phosphorylated sites associate with high affinity to certain cellular proteins. IRS-1 thus acts as an adaptor molecule that links the receptor kinase to various cellular activities regulated by insulin. IRS-1 is also phosphorylated after stimulation by insulinlike growth factor-1 and several interleukins.
References in periodicals archive ?
Griendling, "Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Kunjara et al., "Insulin resistance in human preeclamptic placenta is mediated by serine phosphorylation of insulin receptor substrate-1 and -2," The Journal of Clinical Endocrinology and Metabolism, vol.
Steinle, "Silencing of insulin receptor substrate-1 increases cell death in retinal Muller cells," Molecular Vision, vol.
The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307.
Baserga, "The insulin receptor substrate-1: a biomarker for cancer?" Experimental Cell Research, vol 315, no.
Moreover, [ACE2.sup.-/y] mice presented a significant decrease in proteins involved in glycolysis, such as insulin receptor substrate-1 (aIRS-1), phosphatidyl inositol-3 kinase (PI3-K), and AKT compared to WT (Figures 5(c)-5(e)).
Tanti, "Interleukin-1^-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression," Endocrinology, vol.
We studied glucose transporter-4 (GLUT-4) insulin receptor substrate-1 (IRS-1), Insulin receptor (IR), Phosphoenolpyrovate carboxykinase (PEPCK), Sterol regulatory element binding protein-1c (SREBP-1c), Fatty acid synthase (FAS), Peroxisome proliferator-activated receptor-a (PPAR-a), Peroxisome proliferator-activated receptor-g (PPAR-g) and tumor necrosis factor-a (TNF-a) in hepatic, skeletal muscle and adipose tissue.
Moreover, CPEC and its two triterpenoids not only enhanced glucose uptake in an insulin-independent manner, but also restored insulin-mediated protein kinase B (Akt) phosphorylation by reducing the activation of IKK[beta] and regulating insulin receptor substrate-1 (IRS-1) serine/tyrosine phosphorylation.
C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 in L6 myocytes thereby impairing the insulin signalling pathway that promotes glucose transport.
In fact, the insulin receptor substrate-1 Gly972Arg variant is widely studied in terms of its relationship to diabetes mellitus.
[29] have shown that tyrosine nitration of the insulin receptor substrate-1 reduces insulin stimulated glucose uptake.

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