insulin receptor


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INSR

A gene on chromosome 19p13.3-p13.2 that encodes insulin receptor, the binding of insulin to which stimulates glucose uptake.

Molecular pathology
Defects of INSR cause Rabson-Mendenhall syndrome, leprechaunism and hyperinsulinaemic hypoglycaemia type 5.

insulin receptor

A heterodimeric membrane receptor composed of α and
β chains, which has tyrosine kinase activity after binding insulin; IR deficiency is a rare cause of DM and may be due to a gene rearrangement, causing a deletion in the tyrosine kinase domain, a point mutation with a loss of the ATP binding site or other genetic defect
References in periodicals archive ?
Insulin receptors (IR) are also overexpressed in cancers and they form hybrid receptors that are a cross between IGFR and IR so that both insulin and IGF-1 will activate them.
Upregulation of the insulin receptor and type I insulin-like growth factor receptor are early events in hepatocarcinogenesis.
Its hepatic production is induced by primary wave cytokines, such as interleukin-1 and tumor necrosis factor alpha, which may interfere with insulin receptor functioning and cause insulin resistance.
Support for the involvement of zinc in phosphorylation of the insulin receptor was provided by Haase and Maret [4] who identified PTP1B as a sensitive target of zinc ions and an important regulator of the phosphorylation state of the insulin receptor.
1994, Molecular scanning of the Insulin receptor gene in syndromes of insulin resistances, Diabetes.
Could you have predicted that insulin and the insulin receptor would be such a rich field?
Binding of insulin to extracellular [alpha] subunits of insulin receptor (INSR) leads to activation of intrinsic tyrosine kinase and autophosphorylation of its [beta] subunits.
Reducing the activity of the IRS (for insulin receptor substrate) gene caused bees to forage more for pollen than for nectar, report researchers led by Gro Amdam of Arizona State University in Tempe and the Norwegian University of Life Sciences in Aas.
The study concluded that insulin receptor signaling downregulated the oligomeric binding sites.
This appeared to influence a gene called insulin receptor substrate 1, or IRS1.
In this study, the effects of the extract and four tanshinone compounds from the dried root of Salvia miltiorrhiza Bunge (Labiatae) on the tyrosine phosphorylation of the insulin receptor (IR) [beta]-subunit and the downstream signaling were examined in Chinese-hamster ovary cells expressing human insulin receptors (CHO/IR cells) as well as in 3T3-L1 adipocytes.

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