insulin autoantibodies

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Related to insulin autoantibodies: GAD antibodies

insulin autoantibodies

IAA

Antibodies to the hormone insulin. They are, in addition to antibodies to glutamic acid decarboxylase and protein tyrosine phosphatase-like molecules, one of the markers of type 1 diabetes mellitus.

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Proinsulin autoantibodies: association with type I diabetes but not with islet cell antibodies, insulin autoantibodies or HLA-DR type.

Autoimmune markers in diabetes

Islet cell autoantibodies comprise autoantibodies to islet cell cytoplasm (ICAs); to native insulin, referred to as insulin autoantibodies (IAAs) (208); to glutamic acid decarboxylase ([GAD.sub.65]A) (209-211); and to two tyrosine phosphatases [insulinoma-associated antigens IA-2A (212) and IA-2[beta]A (213)].

GAD65 autoantibodies increase the predictability but not the sensitivity of islet cell and insulin autoantibodies for developing insulin dependent diabetes mellitus.

Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus

Insulin autoantibodies are common in patients receiving exogenous insulin, but they can also be observed in individuals never treated with insulin, particularly in patients with autoimmune diseases [up to 30% (2)].

Autoimmune hypoglycemia presenting as seizure one week after surgery

The diagnostic sensitivity of insulin autoantibodies is age dependent and decreases with increasing age.

Interactions of age, islet cell antibodies, insulin autoantibodies, and first-phase insulin response in predicting risk of progression to IDDM in ICA(+) relatives: the ICARUS data set.

Type I diabetes

Islet cell antibodies (ICA), insulin autoantibodies (IAA), islet cell surface antibodies (ICSA) and C-peptide in 1031 school children in a population with a high background incidence of IDDM.

Protein tyrosine phosphatase-like protein IA2-antibodies plus glutamic acid decarboxylase 65 antibodies (GADA) indicates autoimmunity as frequently as islet cell antibodies assay in children with recently diagnosed diabetes mellitus

Islet cell antibodies [ICA], insulin autoantibodies [IAA], islet cell surface antibodies [ICSA] and C-peptide in 1031 school children in a population with a high background incidence of IDDM.

Measurement of antibodies against glutamic acid decarboxylase 65 (GADA): two new [sup.125]I assays compared with [[sup.35]S]GAD 65-ligand binding assay