insulin aspart

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insulin aspart (rDNA origin)


insulin aspart and insulin aspart protamine

NovoLog Mix 70/30

Pharmacologic class: Pancreatic hormone

Therapeutic class: Hypoglycemic

Pregnancy risk category C


Short-acting insulin form. Promotes glucose transport, which stimulates carbohydrate metabolism in skeletal and cardiac muscle and adipose tissue. Also promotes phosphorylation of glucose in liver, where it's converted to glycogen. Directly affects fat and protein metabolism, stimulates protein synthesis, inhibits release of free fatty acids, and indirectly decreases phosphate and potassium.


Injection (NovoLog): 100 units/ml in 10-ml vials and 3-ml PenFill cartridges

Injection (NovoLog Mix 70/30): 100 units/ml in 10-ml vials, 3-ml PenFill cartridges, and 3-ml FlexPen prefilled syringes

Indications and dosages

Type 1 (insulin-dependent) diabetes mellitus; type 2 (non-insulin-dependent) diabetes mellitus

Adults and children ages 6 and older: Insulin aspart-Dosage tailored to patient's needs, given subcutaneously in divided doses 5 to 10 minutes before meals. Insulin aspart provides 50% to 70% of dose; intermediate or long-acting insulin provides remainder. Dosage range is 0.5 to 1 unit/kg/day in divided doses based on meals. Insulin aspart and insulin aspart protamine- Give subcutaneously b.i.d., 15 minutes before morning and evening meals. For monotherapy, initial dosage is 0.4 to 0.6 unit/kg/day in two divided doses. Titrate in increments of 2 to 4 units q 3 to 4 days to achieve target fasting plasma glucose level. When given with oral hypoglycemics, initial dosage is 0.2 to 0.3 unit/kg/day.


• Hypersensitivity to drug or its components

• Hypoglycemia


Use cautiously in:

• hepatic or renal impairment, hypothyroidism, hyperthyroidism

• elderly patients

• pregnant or breastfeeding patients

• children.


Be aware that insulin is a high-alert drug.

• Know that drug is bioavailable as regular human insulin but has a faster onset and shorter duration.

• Give by subcutaneous route only, 5 to 10 minutes (15 minutes for Novolog Mix 70/30) before a meal.

• When mixing insulin aspart with intermediate or long-acting insulin, draw up insulin aspart into syringe first.

Don't mix insulin aspart protamine with any other insulin.

• When giving insulin aspart by pump, don't mix with other insulins.

• Rotate injection sites to prevent lipodystrophy.

Adverse reactions

Metabolic: hypokalemia, sodium retention, hypoglycemia, rebound hyperglycemia (Somogyi effect)

Musculoskeletal: myalgia

Skin: urticaria, rash, pruritus

Other: edema; lipodystrophy; lipohypertrophy; redness, warmth, or stinging at injection site; allergic reactions including anaphylaxis


Drug-drug. Acetazolamide, albuterol, antiretrovirals, asparaginase, calcitonin, corticosteroids, cyclophosphamide, danazol, dextrothyroxine, diazoxide, diltiazem, diuretics, dobutamine, epinephrine, estrogens, hormonal contraceptives, isoniazid, morphine, niacin, phenothiazines, phenytoin, somatropin, terbutaline, thyroid hormones: decreased hypoglycemic effect

Anabolic steroids, angiotensin-converting enzyme inhibitors, calcium, chloroquine, clofibrate, clonidine, disopyramide, fluoxetine, guanethidine, mebendazole, MAO inhibitors, octreotide, oral hypoglycemics, phenylbutazone, propoxyphene, pyridoxine, salicylates, sulfinpyrazone, sulfonamides, tetracyclines: increased hypoglycemic effect

Beta-adrenergic blockers (nonselective): masking of some hypoglycemia signs and symptoms, delayed recovery from hypoglycemia

Lithium carbonate: decreased or increased hypoglycemic effect

Pentamidine: increased hypoglycemic effect, possibly followed by hyperglycemia

Drug-diagnostic tests. Glucose, inorganic phosphate, magnesium, potassium: decreased levels

Liver and thyroid function studies: test interference

Urine vanillylmandelic acid: increased level

Drug-herbs. Basil, bee pollen, burdock, glucosamine, sage: altered glycemic control

Chromium, coenzyme Q10, dandelion, eucalyptus, fenugreek, marshmallow: increased hypoglycemic effect

Garlic, ginseng: decreased blood glucose level

Drug-behaviors. Alcohol use: increased hypoglycemic effect

Marijuana use: increased blood glucose level

Smoking: increased blood glucose level, decreased response to insulin

Patient monitoring

• Monitor blood glucose level frequently to gauge drug efficacy and appropriateness of dosage.

• Watch blood glucose level closely if patient is converting from one insulin type to another or is under unusual stress (as from surgery or trauma).

Stay alert for signs and symptoms of hypoglycemia. Keep glucose source at hand.

Assess for evidence of hyperglycemia, such as polydipsia, polyphagia, polyuria, and diabetic ketoacidosis (as shown by urine and blood ketones, metabolic acidosis, extremely elevated blood glucose level, and hypovolemia).

• Monitor for glycosuria.

• Closely monitor kidney and liver function test results in patients with renal or hepatic impairment.

Patient teaching

• Teach patient how to administer insulin subcutaneously or by injection pen.

• If patient must mix insulin aspart with intermediate or long-acting insulin, instruct him to draw up insulin aspart into syringe first.

Tell patient not to mix any other insulin with mixture of insulin aspart and insulin aspart protamine.

• Advise patient to rotate subcutaneous injection sites and keep a record of sites used, to help prevent fatty tissue breakdown.

Teach patient how to recognize and report signs and symptoms of hypoglycemia and hyperglycemia. Advise him to always carry a glucose source.

• Inform patient that changes in diet, activity, and stress level affect blood glucose levels and insulin requirements.

• Teach patient how to monitor and record blood glucose level and, if indicated, urine glucose and ketone levels.

• Tell patient to wear medical identification stating that he is diabetic and takes insulin.

• Instruct patient to have regular medical, vision, and dental exams.

• Tell female patient to contact prescriber if she is pregnant or plans to become pregnant.

• Advise patient to store insulin in refrigerator, not freezer.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

insulin aspart

A rapid-acting insulin analog whose amino acid sequence differs from that of human insulin by the substitution of aspartic acid for proline in the B chain, used in the treatment of type 1 and type 2 diabetes.
References in periodicals archive ?
Baseline characteristics of the treatment groups Insulin Lispro Insulin Aspart p-value Premix 50/50 Premix 70/30 Gender (F/M) 28/32 28/34 0.886 Age (years) * 60 (24-84) 65 (39-90) 0.005 Duration of diabetes (years) * 8.0 (0-36) 9.5 (0-37) 0.04 BMI (kg/[m.sup.2]) * 30 (27-36) 29 (26-36) 0.814 Complications (%) Any microvascular 10 12 0,871 Any macrovascular 5 6 0.869 Co-existing disease (%) Hypertension 40 58 0.201 Hyperlipidemia 68 76 0.334 Table 2.
According to the company, Fiasp is an innovative formulation of insulin aspart that more closely matches the natural physiological insulin response of a person without diabetes, after a meal, compared with NovoRapid (conventional insulin aspart).
Novo Nordisk has also begun the Phase IIIa clinical program, Onset, for faster-acting or formulation of insulin aspart. The improved formulation is intended to enable a faster onset of appearance of insulin in the bloodstream.
Efficacy and safety of biphasic insulin aspart 30 combined with pioglitazone in type 2 diabetes poorly controlled on glibenclamide (glyburide) monotherapy or combination therapy: an 18 week, randomized, open-label study Clin Ther 2005; 27:1432-1443.
X One dose of IDeg Asp may be taken with suhur, along with one dose of insulin aspart at iftar, to cover the high carbohydrate content of the iftar meal.
A third insulin analogue on the market, insulin glulisine (Apidra), approved in 2004, has a pharmacokinetic profile that is similar to insulin aspart and lispro.
Insulin aspart premix 70/30 contains rapid-acting insulin aspart, of which 70% has been protaminated to extend the duration of action to provide for a basal insulin component.
NovoRapid PumpCart, containing the company's NovoRapid (insulin aspart) rapid-acting insulin, is anticipated to make insulin pump treatment more convenient for diabetics and their care staff.
Ten years of experience with biphasic insulin aspart 30: from drug development to the latest clinical findings.
Also, Ryzodeg, the brand name for insulin degludec/insulin aspart, contains the new generation once-daily basal insulin degludec in a soluble formulation with insulin aspart.