insulin antibody

insulin antibody

Any anti-insulin autoantibody that develops in diabetics receiving insulin. See Insulin.
References in periodicals archive ?
Prediluted primary anti-mouse insulin antibody (1:1000), anti-mouse glucagon antibody (1:2000) (Sigma, USA).
Another study published in 2007 reported a similar insulin antibody response--and placental passage--in women with gestational diabetes mellitus (GDM) who were receiving human insulin (Diabetes Care 1997;20:1172-5).
Once insulin is exogenously administered (for >10 days) the IAA determination is no longer valid because exogenous insulin injection can elicit insulin antibody responses that cannot be distinguished from autoantibody production.
Insulin antibody levels and other laboratory tests monitoring safety were similar for both groups.
Observations were made regarding insulin antibody levels, weight gain, body mass index, and hypoglycemic events.
The striking facts in terms of the present cases were the presence of negative ICA and anti-GAD antibodies in both cases and the increased insulin antibody titers at the end of the 3rd year in the 74-year-old female during the time period that the hypoglycemic attacks occurred.
1) Orally administered insulin can result in massive insulin antibody production from plasma cells (in lamina propria).
The study will also investigate the incidence of hypoglycaemic events, insulin antibody formation, glycaemic control and overall treatment satisfaction.
In studies of patients with type 2 diabetes who had previously received insulin, insulin antibody levels were approximately 6% with inhaled insulin compared to less than 3% with SC insulin; in patients with no previous insulin use, levels were identical with both formulations (<3%).
Yalow and Berson were able to raise an insulin antibody, leading to the development of the RIA for insulin and opening the door to other immunoassays (FPIA, ELISA, Emit) that did not require radioactive tracers.