Oral dosages of another experimental HNO prodrug, CXL-1036, produced enhanced inotropy
(systolic pump function), lusitropy (diastolic relaxation) and vasodilation while decreasing cardiac energy demand in animal models.
Howlett, Increases in diastolic [Ca2+] can contribute to positive inotropy
in guinea pig ventricular myocytes in the absence of changes in amplitudes of Ca2+ transients.
Its slower and longer (up to 72 hours) duration of action, relative lack of negative inotropy
, and once-daily dosing has made it preferred over other calcium channel blockers (CCBs) such as verapamil or nifedipine.
L-NAME in combination with DECC did not change the negative inotropy
, negative chronotropy and the decrease in coronary flow induced by DECC.
Adrenaline was substituted for noradrenaline to enhance inotropy
We found that TA (AqE) decoctions exerted positive inotropy
, accelerated myocyte relaxation and increased caffeine-induced contraction concentration-dependently.
This negative inotropy
of the apex relative to the base of the ventricle brings about the characteristic ballooning seen on catheterization of patients with takotsubo cardiomyopathy.
These results are compatible with known pharmacological effects of Crataegus extracts such as WS[R] 1442: Positive inotropy
by inhibition of myocardial [Na.
Effects of preload, afterload and inotropy
on PV loops
The goal of therapy in PPCM is reductions in both preload and afterload plus increased inotropy
S-(-)-cathinone and its major metabolite S-(-)-norephedrine caused coronary vasoconstriction, negative inotropy
and negative chronotropy in guinea-pig-isolated perfused hearts (Al-Motarreb & Broadley 2003).
In athlete's heart, this is reflected in better inotropy
, lusitropy, and augmented cardiac pumping capacity (Katz and Lorell, 2000), which are clearly an advantage.