inotropic

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Related to inotropism: positive inotropic agent

inotropic

 [in″o-trop´ik]
affecting the force of muscular contractions.

in·o·tro·pic

(in'ō-trop'ik),
Influencing the contractility of muscular tissue.
[ino- + G. tropos, a turning]

inotropic

(ē′nə-trō′pĭk, -trŏp′ĭk, ī′nə-)
adj.
Affecting the contraction of muscle, especially heart muscle: an inotropic drug.

in·o·tro·pic

(in'ō-trō'pik)
Influencing the contractility of muscular tissue.
[ino- + G. tropos, a turning]

inotropic

Influencing the force or speed of muscular contractility. Inotropic agents, such as dobutamine and dopamine are used to improve the output of the heart in the treatment of HEART FAILURE and sometimes in acute circulatory failure (SHOCK).

inotropic

affecting or controlling the strength of heart contractions. For example, chemicals that increase the force of contraction have a positive inotropic effect.
References in periodicals archive ?
R(+)-pulegone impairs [Ca.sup.2+] homeostasis and causes negative inotropism in mammalian myocardium.
When the patient "moves" in phase 1 of the curve, preload is directly proportional to the systolic volume; the variations of pulse are broad, indicating that the patient is dependent on the preload or that the patient will respond to the volumen (2,3,10) (responder or dependent on volume), while if the patient is moved to phase 2 of the Starling curve the variations in pulse pressure are minimal, indicating that the patient will not respond to the liquid infusion or that what is probably required is to strengthen cardiac inotropism to increase cardiac output and avoid an overload of liquids that can lead to pulmonary edema (2,3,10) (non-responder or not dependent on volume).
Levosimendan activates [K.sub.ATP] channels in rat isolated cardiac mitochondria (52) (Figure 2) and ventricular cells (6) with [EC.sub.50] values of 0.83 and 4.7 [micro]M, respectively; values which are different from those required for inotropism. Further, during ischaemia, as the intracellular ADP: adenosine triphosphatase (ATP) ratio increases, the potency of levosimendan may be potentially enhanced.
Rather, it can be attributed to enhanced mental alertness or an increase in a phenomenon scientists call cardiac inotropism. Actual changes in blood pressure cannot be "felt."
In the heart, the release of [Ca.sup.2+] from intracellular stores leads to an increase of heart rate and cardiac inotropism and to vasodilatation [36-38].
BP studies have shown the following in vitro effects in rodent tissue: positive inotropism, sedation, analgesic activity, H1 antagonism (ileum, bronchial muscle, peripheral vasculature), and antimicrobial activity (Oliver-Bever 1983; Pal et al.
Heart rate, cardiac inotropism and, hence, blood pressure (BP) increase with stimulation of [[beta].sub.1] adrenergic receptors and decrease with their blockade.