inotropic agent


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inotropic agent

a substance that influences the force of muscular contractions; an agent that increases the force of muscular contractions of the heart.

inotropic agent

Positive inotropic agent Cardiology A therapeutic agent that ↑ the strength and/or force of myocardial contraction; 2 major classes of positive inotropes: those that ↑ intracellular cAMP by stimulating the β-adrenergic receptor or inhibiting phosphodiesterase–eg, milrinone and those that ↑ intracellular sodium–eg, digoxin, vesnarinone, see there.
References in periodicals archive ?
Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium.
The change rate in cardiac output and S1 amplitude changed according to the administration of the inotropic agent and beta blocker.
A positive inotropic agent that simultaneously activates intracellular [K.
Patients treated with the vasodilator nitroglycerin or the natriuretic peptide nesiritide had better survival rates and shorter hospital stays than did those treated with the positive inotropic agents dobutamine and milrinone, the researchers said.
Intravenous positive inotropic agents are commonly used to treat the patients with acute decompensated heart failure due to left ventricular systolic dysfunction.
Although it is routinely used for chronic heart failure exacerbations and is FDA approved for that indication, no placebo-controlled trials have established that milrinone or other intravenous inotropic agents improve outcomes, the investigators said (JAMA 287[12]:1541-47, 2002).
Patient's capillary withdrawal time was prolonged (>5 sec) and were given inotropic agents, vasopressor support and saline challange twice a day (20 cc/kg) Her blood gases were; pH 6,56, pCO2: 104 mmHg, HCO3:9,2 mmol/L, Be:-31,6, lactat: 16,32 mmol/L at her admission.
The control group was given continuous low flow oxygen inhalation and inotropic agents, and their cardiac stress was also reduced.
Suggested escalating levels of treatment include no treatment for an abnormality on radiography alone; nasal supplemental oxygen for mild hypoxemia; continuous positive airway pressure through face mask for moderate hypoxemia[9] and intubation, mechanical ventilation, and positive end-expiratory pressure for severe hypoxemia; and volume replacement and inotropic agents for hypotension with low cardiac output.