inositol 1,4,5-trisphosphate

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in·o·si·tol 1,4,5-·tris·phos·phate (IP3),

a second messenger formed from phosphatidylinositol 4,5-bisphosphate; triggers the release of calcium ions from special vesicles of the endoplasmic reticulum; has a role in the activation of neutrophils.


a cyclic sugar alcohol, C6H12O6; usually referring to the most abundant isomer, myo-inositol, which is found in many plant and animal tissues.

inositol 1,4,5-trisphosphate
intracellular second messenger released from phosphatidyl 4,5-bisphosphate in response to agonist-dependent, GTP-G protein-activated phospholipase C. Called also IP3. Causes release of Ca2+ from intracellular stores, thereby activating calmodulin.
References in periodicals archive ?
A new inositol 1,4,5-trisphosphate binding protein similar to phospholipase C-d 1 [85].
Expression and characterization of an inositol 1,4,5-trisphosphate binding domain of phosphatidylinositol-specific phospholipase CD1 [74].
Detection and partial purification of inositol 1,4,5-trisphosphate 3-kinase from porcine skeletal muscle.
A novel A-isoform-like inositol 1,4,5-trisphosphate 3-kinase from chicken erythrocytes exhibits alternative splicing and conservation of intron positions between vertebrates and invertebrates [90].
Streb H, Irvine RF, Berridge MJ, Schulz (1983) Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol 1,4,5-trisphosphate.
1995) Inositol 1,4,5-trisphosphate binding to porcine tracheal smooth muscle aldolase.
Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate.
2+]) whose redox properties can enhance the activity of the inositol 1,4,5-trisphosphate receptor (I[P.
2+] flux through inositol 1,4,5-trisphosphate receptor type 1 but not type 3 via modulation of an isoform-specific [Ca.
Purified reconstituted inositol 1,4,5-trisphosphate receptors.