inosine


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Related to inosine: inosine pranobex

inosine

 (I) [in´o-sēn]
a purine nucleoside containing the base hypoxanthine and the sugar ribose, which occurs in transfer RNAs.
inosine monophosphate (IMP) a nucleotide produced by removal of the amine group from adenosine monophosphate in metabolism of purine nucleotides.

in·o·sine (I, Ino),

(in'ō-sēn),
9-β-d-Ribosylhypoxanthine; a nucleoside formed by the deamination of adenosine.
Synonym(s): hypoxanthinosine

inosine

/in·o·sine/ (I) (in´o-sēn) a purine nucleoside containing the base hypoxanthine and the sugar ribose, which occurs in transfer RNAs and as an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage.
inosine monophosphate  (IMP) a nucleotide produced by the deamination of adenosine monophosphate (AMP); it is the precursor of AMP and GMP in purine biosynthesis and an intermediate in purine salvage and in purine degradation.

inosine

(ĭn′ə-sēn′, -sĭn, ī′nə-)
n.
A nucleoside that is involved in purine metabolism, as a precursor and a metabolite of adenosine.

inosine

[in′əsēn, -sīn]
a nucleoside derived from animal tissue, especially intestines, originally used in food processing and flavoring. It has been used in the treatment of cardiac disorders and is now under investigation in studies of cancer and virus chemotherapy. See also inosiplex.

in·o·sine

(I, Ino) (in'ō-sēn)
A nucleoside formed by the deamination of adenosine.

inosine (I)

a NUCLEOSIDE found in some ANTICODONS of TRANSFER RNA. Inosine is ribosylhypoxanthine, the base being hypoxanthine, a derivative of ADENINE. Inosine generally occurs in the first position of the anticodon of certain tRNA molecules where it can base pair with U, C or A of the CODON on mRNA.

inosine

a nucleic acid derivative found naturally in brewer's yeast and organ meats. Not essential in the diet since the body can synthesize it from amino acids and glucose. Metabolically, takes part in formation of adenine, a component of ATP. It has been suggested that inosine supplementation might enhance exercise performance by increasing ATP supply but research studies have found no improvements. See also ergogenic aids; appendix 4.4 .

inosine (īˑ·nō·sēn),

n a nucleoside and precursor to adenosine, important biochemical in energy production. It may be useful as an adjunct treatment for cardiovascular conditions and for Tourette's syndrome. High doses may increase the levels of uric acid in the blood.

inosine

a purine nucleoside containing the base hypoxanthine and the sugar ribose, which occurs in transfer RNAs.

inosine monophosphate (IMP)
a nucleotide produced by the deamination of adenosine monophosphate (AMP) in the metabolism of purine nucleotides.
inosine 5-monophosphate
the first fully formed purine nucleotide in the pathway of purine synethesis. Called also IMP or inosinic acid.
References in periodicals archive ?
Selective up-regulation of type II inosine 5'-monophosphate dehydrogenase messenger RNA expression in human leukemias.
We intend to find out whether inosine can be used as a protective therapy to delay Parkinson's in people at risk and slow disease progression in those already diagnosed," said lead investigator Michael Schwarzschild, MD, PhD, of Massachusetts General Hospital.
Higher levels of taste in BL breast meat can be attributed to the greater IMP and inosine contents found in this meat (Table 3).
Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice.
Other germination mutants, such as gerP (which lacked inosine receptors) and gerN (which lacked germinant-transfer proteins), were also deficient in pressure-induced germination.
In the study, Inosine was shown to stimulate nerve cells in undamaged parts of the brain to grow new connections into brain areas that had lost their normal connections as a result of a stroke; this "rewiring" partially compensated for the loss of the original connections, and resulted in significant improvement in several types of behavior compared to rats that did not receive Inosine.
The compound, called inosine, induces nerve fibers to grow and reconnect in the brain and spinal cord, say the researchers.
MPA inhibits inosine monophosphate dehydrogenase, an enzyme involved in the guanosine nucleotide synthesis pathway.
Section 4 - Thermally Generated Flavour includes Studies on Intermediates Generating the Flavour Compounds 2-Methyl-3-furanthiol, 2-Acetyl-2-thiazoline and Sotlon by Maillard-type Reactions; New Aspects of the Formation of 3(2H)-Furanones through the Maillard Reaction; Off-Flavour Formation in the Heat Sterilized Meat in Trays; Studies on the Aroma of Roasted Coffee; Comparison of Three Sugars and Inosine Monophosphate as Precursors of Meat Aroma; Olfactometric Study of Cooked Cured Ham; Comparison of Some Aroma Impact in Roasted Coffee and Coffee Surrogates; Influence of Blanching on Aroma Compounds in Leeks during Frozen Storage.
The levels of inosine, lysine, putrescine and xanthine correlated with the therapeutic effects of brushing with CT, a triclosan-containing dentrifice, against gingivitis and provided biochemical confirmation that CT can provide therapeutic improvement against gingivitis.
Since inosine is biochemically read as guanosine, A-to-I editing alters genomic information on the RNA-level and may potentially allow for the manipulation of RNA processing or protein function.