inorganic pyrophosphatase


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in·or·gan·ic py·ro·phos·pha·tase

a phosphohydrolase catalyzing hydrolysis of inorganic pyrophosphate to two orthophosphates.
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PPi is hydrolyzed to inorganic phosphate by alkaline phosphatase (ALP) and inorganic pyrophosphatases. In hypophosphatasia, a congenital condition due to a mutation in ALPL, decreased ALP levels lead to excess accumulation of inorganic pyrophosphatases (12).