Pimobendan is a benzimidazole-pyridazinone derivative that functions as an arteriodilator, venodilator, and positive inotrope, and is therefore classified as an inodilator
(9, 17, 21).
Our patient, with a LVEF of 12% and LVDD of 49 mm --diagnosed by exclusion more than 15 days after the initial visit-required invasive ventilation, vasopressor, inotropic and inodilator
(levosimendan) support on two occasions.
Pimobendan, an inodilator
has been found to reduce morbidity in CHF (Fuentes, 2004).
Pimobendan is a benzimidazole-pyridazone derivative and a novel cardiotonic vasodilator (inodilator
A phosphodiesterase-3-inhibitor (milrinone, load 25 [micro]g/kg and infusion 0.5 [micro]g/kg/ minute) was instituted as an inodilator
to increase myocardial contractility and reduce ventricular afterload.
In that study, we showed the novel inodilator
agent levosimendan improved LA performance in patients with severe HF receiving optimal conventional treatment.
Coronary vasorelaxant effect of levosimendan, a new inodilator
with calcium-sensitizing properties.
Comparison of the vasorelaxing effect of cromakalim and the new inodilator
, levosimendan, in human isolated portal vein.
Levosimendan, a new inodilator
used in the treatment of decompensated heart failure, has been reported to be effective in patients with high perioperative risks, with abnormal left ventricular function, and who face difficulties in weaning off cardiopulmonary bypass (3).
Commonly known as an 'inodilator
', it causes marked arterial vasodilation and has a positive inotropic effect, which together increase cardiac output and decrease systemic vascular resistance.
Levosimendan, a novel inodilator
, may represent a therapeutic option in those patients who require improved right ventricular performance and reduced pulmonary vascular tone.
Adrenaline acted as an inoconstrictor, dobutamine an inodilator
and milrinone predominantly a vasodilator.