Pimobendan is a benzimidazole-pyridazinone derivative that functions as an arteriodilator, venodilator, and positive inotrope, and is therefore classified as an
inodilator (9, 17, 21).
Pimobendan, an
inodilator has been found to reduce morbidity in CHF (Fuentes, 2004).
Pimobendan is a benzimidazole-pyridazone derivative and a novel cardiotonic vasodilator (
inodilator).
A phosphodiesterase-3-inhibitor (milrinone, load 25 [micro]g/kg and infusion 0.5 [micro]g/kg/ minute) was instituted as an
inodilator to increase myocardial contractility and reduce ventricular afterload.
In that study, we showed the novel
inodilator agent levosimendan improved LA performance in patients with severe HF receiving optimal conventional treatment.
Coronary vasorelaxant effect of levosimendan, a new
inodilator with calcium-sensitizing properties.
Comparison of the vasorelaxing effect of cromakalim and the new
inodilator, levosimendan, in human isolated portal vein.
Levosimendan, a new
inodilator used in the treatment of decompensated heart failure, has been reported to be effective in patients with high perioperative risks, with abnormal left ventricular function, and who face difficulties in weaning off cardiopulmonary bypass (3).
Commonly known as an '
inodilator', it causes marked arterial vasodilation and has a positive inotropic effect, which together increase cardiac output and decrease systemic vascular resistance.
Levosimendan, a novel
inodilator, may represent a therapeutic option in those patients who require improved right ventricular performance and reduced pulmonary vascular tone.
Adrenaline acted as an inoconstrictor, dobutamine an
inodilator and milrinone predominantly a vasodilator.