DAPI: 4',6-diamidino- 2-phenylindole; IHC: inner hair cell
; P: postnatal day.
(d) The stereocilia of inner hair cells
become sharp in Myo3a mutant mice at the age of 2 months, 6 months, and 12 months.
Glowatzki, "Two modes of release shape the postsynaptic response at the inner hair cell
ribbon synapse," The Journal of Neuroscience, vol.
Green, "Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells
after excitotoxic trauma in vitro," Journal of Neuroscience, vol.
Histopathologic studies have shown that outer hair cells are more sensitive to ototoxic injury than are inner hair cells
. We also know that the aminoglycosides are transported into the hair cells themselves, but they probably do not concentrate there.
At E15.5, myosin7a was clearly expressed in developing inner hair cells
, but not in the developing outer hair cells (OHCs) at the basal end of the cochlea (Figure 2, A4-A5).
Hearing starts with the transmission of sound by inner hair cells
in the ear.
The hypothesis that subjective tinnitus is primarily caused by glutamate excitotoxicity at the synapses between inner hair cells
and their afferents in the cochlea has been confirmed.
The outer hair cells are much more susceptible to injury than are the inner hair cells
. (6) Among the outer hair cells, those in the inner row are the most susceptible; those in the middle row are less susceptible, and those in the outer row are the least susceptible (figure 1).
The fibers that originate in the lateral area of the upper olivary complex extend through the ipsilateral cochlea and end under the nerve fibers on the inner hair cells
. The fibers that originate in the median area of the upper olivary complex extend through the contralateral cochlea down to the outer hair cells.
Inner hair cells
(IHCs) and outer hair cells (OHCs) are two types of sensory cells in the mammalian cochlea.
In mammalian inner ear, transduction by Ad vectors is organ (cochlea versus vestibule), cell type (inner hair cells
(IHCs), outer hair cells (OHCs), and supporting cells (SCs)), region (base, middle, and apical turns), and age dependence.