innate immunity


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.

in·nate im·mu·ni·ty

resistance manifested by a species (or by races, families, and individuals in a species) that has not been immunized (sensitized, allergized) by previous infection or vaccination; much of it results from body mechanisms that are poorly understood but differ from those responsible for the altered reactivity associated with the specific nature of acquired immunity; in general, innate immunity is nonspecific and is not stimulated by specific antigens.
See also: self.
Synonym(s): natural immunity, nonspecific immunity

innate immunity

innate immunity

The nonspecific first line of defence against foreign pathogens that is an integral facet of the immune response, which is mediated by dendritic cells (DCs), natural killer (NK) cells, macrophages, neutrophils, basophils, eosinophils and mast cells. Macrophages and mast cells serve as sentinels stationed in tissues, which continuously monitor their microenvironment for signs of distress.

in·nate im·mu·ni·ty

(i-nāt' i-myū'ni-tē)
Resistance manifested by an organism that has not been sensitized by previous infection or vaccination; innate immunity is nonspecific and is not stimulated by specific antigens.
See also: self
Synonym(s): natural immunity, nonspecific immunity.

innate immunity,

n the ability of the body to protect itself against foreign organisms and toxins. The defense mechanisms of skin, white blood cells, macrophages, stomach acid, and chemicals in the bloodstream are all part of innate immunity.

in·nate im·mu·ni·ty

(i-nāt' i-myū'ni-tē)
Resistance manifested by an organism that has not been sensitized by previous infection or vaccination; nonspecific and is not stimulated by specific antigens.
Synonym(s): natural immunity, nonspecific immunity.
Mentioned in ?
References in periodicals archive ?
Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
Asthma and innate immunity; current perspective
The innate immunity is also termed as non-specific immunity, which acts as first line of bastille against infectious agents like intracellular bacteria (e.
VIRULENCE FACTORS, INTRACELLULAR SURVIVABILITY AND MECHANISM OF EVASION FROM HOST IMMUNE RESPONSE BY BRUCELLA: AN OVERVIEW
SP-A and SP-D are hydrophilic proteins belonging to the collectin family of innate immunity proteins and are secreted from epithelial surfaces.
Expression of Innate Immunity Genes in Epithelial Cells of Hypertrophic Adenoids with and without Pediatric Chronic Rhinosinusitis: A Preliminary Report
This study also provided evidence that Cistanche extracts have beneficial effects on innate immunity as well, by boosting levels of natural killer (NK) cells and reducing levels of the pro-inflammatory cytokine interleukin-6 (IL-6).
Immune-boosting strategy for longevity
The critical involvement of innate immunity in host defence is underscored by the recurrent and chronic life-threatening infections associated with:
Innate immunity: innate immune mechanisms confer essential first-line host defence against the unrelenting threat posed by environmental microbial and viral pathogens
Ficolins are pattern-recognition lectins involved in the lectin-complement pathway; they play an important role in innate immunity (6).
Innate immune response by ficolin binding in apoptotic placenta is associated with the clinical syndrome of preeclampsia
Professor Anthony Segal, of University College London, who led the research, reported in a medical journal: "Our investigations identified defective innate immunity in Crohn's disease.
Viagra could be taken in the treatment of Crohn's disease
For instance, the discovery of the importance of the toll-like receptors in innate immunity in mammals occurred as a direct result of the observation that a defective receptor in flies caused them to be much more susceptible to Aspergillus fumigatus (Lemaitre et al.
Environmental genomics: an opportunity for the NIEHS
ANA975, an organ prodrug of Anadys' small molecule compound isatoribine, belongs to a new class of drugs being developed to regulate innate immunity by interacting with TLR7.
Novartis AG signs license with Anadys Pharmaceuticals to develop, commercialize new HCV, HCB treatments; completes Hexal acquisition
Based on current needs of pediatric medicine in China, the scholars' study will relate to one of eight areas including: human milk protective factors in relation to risk of viral infections, maintaining healthy skin in young children and prematurity and innate immunity.
Pampers and Children's Hospital reach out to China
The cell surface receptors of macrophages such as the TLR2 (toll-like receptor), TLR4, and FcaRI are important in innate immunity response, which includes inflammation and cytokine release in response to stimuli.
Immunity and bacterial endotoxin: adenosine and LPS effects on FCaRI, TLR2, and TLR4 in human macrophages
A component of innate immunity prevents bacterial biofilm development.
Basics of biofilm in clinical otolaryngology

Medical browser ?
Full browser ?