innate immunity


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in·nate im·mu·ni·ty

resistance manifested by a species (or by races, families, and individuals in a species) that has not been immunized (sensitized, allergized) by previous infection or vaccination; much of it results from body mechanisms that are poorly understood but differ from those responsible for the altered reactivity associated with the specific nature of acquired immunity; in general, innate immunity is nonspecific and is not stimulated by specific antigens.
See also: self.

innate immunity

innate immunity

The nonspecific first line of defence against foreign pathogens that is an integral facet of the immune response, which is mediated by dendritic cells (DCs), natural killer (NK) cells, macrophages, neutrophils, basophils, eosinophils and mast cells. Macrophages and mast cells serve as sentinels stationed in tissues, which continuously monitor their microenvironment for signs of distress.

in·nate im·mu·ni·ty

(i-nāt' i-myū'ni-tē)
Resistance manifested by an organism that has not been sensitized by previous infection or vaccination; innate immunity is nonspecific and is not stimulated by specific antigens.
See also: self
Synonym(s): natural immunity, nonspecific immunity.

innate immunity,

n the ability of the body to protect itself against foreign organisms and toxins. The defense mechanisms of skin, white blood cells, macrophages, stomach acid, and chemicals in the bloodstream are all part of innate immunity.

in·nate im·mu·ni·ty

(i-nāt' i-myū'ni-tē)
Resistance manifested by an organism that has not been sensitized by previous infection or vaccination; nonspecific and is not stimulated by specific antigens.
Synonym(s): natural immunity, nonspecific immunity.
References in periodicals archive ?
Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
The innate immunity is also termed as non-specific immunity, which acts as first line of bastille against infectious agents like intracellular bacteria (e.
SP-A and SP-D are hydrophilic proteins belonging to the collectin family of innate immunity proteins and are secreted from epithelial surfaces.
This study also provided evidence that Cistanche extracts have beneficial effects on innate immunity as well, by boosting levels of natural killer (NK) cells and reducing levels of the pro-inflammatory cytokine interleukin-6 (IL-6).
The critical involvement of innate immunity in host defence is underscored by the recurrent and chronic life-threatening infections associated with:
Ficolins are pattern-recognition lectins involved in the lectin-complement pathway; they play an important role in innate immunity (6).
Professor Anthony Segal, of University College London, who led the research, reported in a medical journal: "Our investigations identified defective innate immunity in Crohn's disease.
For instance, the discovery of the importance of the toll-like receptors in innate immunity in mammals occurred as a direct result of the observation that a defective receptor in flies caused them to be much more susceptible to Aspergillus fumigatus (Lemaitre et al.
ANA975, an organ prodrug of Anadys' small molecule compound isatoribine, belongs to a new class of drugs being developed to regulate innate immunity by interacting with TLR7.
Based on current needs of pediatric medicine in China, the scholars' study will relate to one of eight areas including: human milk protective factors in relation to risk of viral infections, maintaining healthy skin in young children and prematurity and innate immunity.
The cell surface receptors of macrophages such as the TLR2 (toll-like receptor), TLR4, and FcaRI are important in innate immunity response, which includes inflammation and cytokine release in response to stimuli.
A component of innate immunity prevents bacterial biofilm development.