innate immunity


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in·nate im·mu·ni·ty

resistance manifested by a species (or by races, families, and individuals in a species) that has not been immunized (sensitized, allergized) by previous infection or vaccination; much of it results from body mechanisms that are poorly understood but differ from those responsible for the altered reactivity associated with the specific nature of acquired immunity; in general, innate immunity is nonspecific and is not stimulated by specific antigens.
See also: self.

innate immunity

The nonspecific first line of defence against foreign pathogens that is an integral facet of the immune response, which is mediated by dendritic cells (DCs), natural killer (NK) cells, macrophages, neutrophils, basophils, eosinophils and mast cells. Macrophages and mast cells serve as sentinels stationed in tissues, which continuously monitor their microenvironment for signs of distress.

in·nate im·mu·ni·ty

(i-nāt' i-myū'ni-tē)
Resistance manifested by an organism that has not been sensitized by previous infection or vaccination; innate immunity is nonspecific and is not stimulated by specific antigens.
See also: self
Synonym(s): natural immunity, nonspecific immunity.

in·nate im·mu·ni·ty

(i-nāt' i-myū'ni-tē)
Resistance manifested by an organism that has not been sensitized by previous infection or vaccination; nonspecific and is not stimulated by specific antigens.
Synonym(s): natural immunity, nonspecific immunity.
References in periodicals archive ?
Akira, "The role of pattern-recognition receptors in innate immunity: update on toll-like receptors," Nature Immunology, vol.
The respiratory microbiome and innate immunity in asthma.Curr Opin Pulm Med.
On the other hand, chemical components on the biota cell wall, even if it is not metabolically active, may stimulate an innate immunity mechanism to facilitate human cellular biological cascades.
As a preliminary study trying to explore the role of adenoidal innate immune function in combined pCRS, we examined messenger RNA (mRNA) levels of several innate immunity genes from adenoidal epithelial cells isolated from AH with and without pCRS.
Some studies suggest that NK cells and even innate immunity do not significantly contribute to the initial control of HBV infection.
For this reason, we consider the possible therapeutic implications of inhibition of pulmonary innate immunity during exacerbations of existing airways disease.
Innate Immunity is simple and efficient due to the following characteristics:
Ficolins can share specificity for N-acetylglucosamine, binding it through their fibrinogen-like domain to trigger the activation of complement and subsequent inflammatory response for innate immunity (17).
To this end, IBT is investing in R&D efforts to develop new assays for innate immunity, immunogenicity and disease-specific biomarkers.
Professor Anthony Segal, of University College London, who led the research, reported in a medical journal: "Our investigations identified defective innate immunity in Crohn's disease.
ANA975, an organ prodrug of Anadys' small molecule compound isatoribine, belongs to a new class of drugs being developed to regulate innate immunity by interacting with TLR7.