injection site reaction

Also found in: Acronyms.

injection site reaction

An allergic, histaminic, or traumatic response of the skin and subcutaneous tissues to any substance introduced with a needle.

Patient care

The injection site should be carefully monitored for redness, swelling, necrosis, or purulence. The size of any injury should be measured and the patient's level of pain assessed. Management may depend on the nature of the introduced substance. In mild cases, topical application of a cold pack may alleviate symptoms. When a reaction occurs at the site of a vesicant injection (e.g., in patients receiving cancer chemotherapy), close monitoring by a physician or the injection of local antidotes may be required. Reactions that result in infection or necrosis may need to be treated with antibiotics or with surgical débridement.

References in periodicals archive ?

Among its side effects were injection site reactions, increases in alanine aminotransferase (ALT) levels, and steatosis.

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Anecdotally, some patients who experience local inflammation and/or the wheal and flare response have used antihistamines prior to their injections of glatiramer acetate to alleviate injection site reactions. Histamine has long been recognized as the prototypical mediator in inflammatory skin conditions, with the [H.sub.1] receptor subtype being associated with many aspects of allergic inflammation in skin (Greaves, 2005).

Effect of oral antihistamine on local injection site reactions with self-administered glatiramer acetate

SAN DIEGO -- Large injection site reactions following the fifth dose of DTaP vaccine appear to be over three times more likely when the injection is given in the arm than in the thigh, Dr.

Fifth DTaP reactions vary with injection location. (Three Times more Likely in Arm than Thigh)

From a pool of the 52-week trial and seven 12-week trials: Local injection site reactions occurred in 3.2% and 3.0% of Repatha-treated and placebo-treated patients, respectively.

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These medications are delivered by intramuscular (IM) or subcutaneous (SC) injections, which have been associated with injection site reactions and other tolerability issues.

Comparison of tolerability and adverse events following treatment with two GnRH agonists in patients with advanced prostate cancer

Injection site reactions were the most common adverse reactions.

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The incidence of injection site reactions in the subcutaneous group was 2.22, and more than 95% of reactions were mild.

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Injection site reactions and systemic adverse events, such as lever, are more common with the high-dose vaccine, hut are generally mild and transient.

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There was a far higher incidence of adverse events overall reported in the vaccine group in the study -- 72.8% versus 41.5% -- primarily due to injection site reactions to Zostavax, researchers reported.

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People who received the high-dose Fluzone vaccine were also more likely to experience injection site reactions and systemic adverse events following vaccination.

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However, while around 25 percent of patients experienced improvement in their symptoms, the improvements were less than those seen with other biologies; the drug also caused more injection site reactions and infections.

Caution advised when taking anakinra

Besides, there were more injection site reactions with the use of anakinra and also the rate of serious infections with anakinra was touching statistical significance when compared to placebo.