Among its side effects were
injection site reactions, increases in alanine aminotransferase (ALT) levels, and steatosis.
Anecdotally, some patients who experience local inflammation and/or the wheal and flare response have used antihistamines prior to their injections of glatiramer acetate to alleviate
injection site reactions. Histamine has long been recognized as the prototypical mediator in inflammatory skin conditions, with the [H.sub.1] receptor subtype being associated with many aspects of allergic inflammation in skin (Greaves, 2005).
SAN DIEGO -- Large
injection site reactions following the fifth dose of DTaP vaccine appear to be over three times more likely when the injection is given in the arm than in the thigh, Dr.
These medications are delivered by intramuscular (IM) or subcutaneous (SC) injections, which have been associated with
injection site reactions and other tolerability issues.
Injection site reactions were the most common adverse reactions.
The incidence of
injection site reactions in the subcutaneous group was 2.22, and more than 95% of reactions were mild.
Injection site reactions and systemic adverse events, such as lever, are more common with the high-dose vaccine, hut are generally mild and transient.
There was a far higher incidence of adverse events overall reported in the vaccine group in the study -- 72.8% versus 41.5% -- primarily due to
injection site reactions to Zostavax, researchers reported.
People who received the high-dose Fluzone vaccine were also more likely to experience
injection site reactions and systemic adverse events following vaccination.
However, while around 25 percent of patients experienced improvement in their symptoms, the improvements were less than those seen with other biologies; the drug also caused more
injection site reactions and infections.
Besides, there were more
injection site reactions with the use of anakinra and also the rate of serious infections with anakinra was touching statistical significance when compared to placebo.