Eukaryotic translation initiation factor
4F architectural alterations accompany translation initiation factor
redistribution in poxvirus-infected cells.
Pathological variants in one of the five genes encoding the five subunits of eukaryotic translation initiation factor
eIF2B has been implicated.
Sonenberg, "Abrogation of translation initiation factor
eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells," The EMBO Journal, vol.
Tisdale, "Increased expression of phosphorylated forms of RNA-dependent protein kinase and eukaryotic initiation factor
2alpha may signal skeletal muscle atrophy in weight-losing cancer patients," British Journal of Cancer, vol.
Hekerman et al., "Selective inhibition of eukaryotic translation initiation factor
2[alpha] dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic [beta]-cell dysfunction and apoptosis," Journal of Biological Chemistry, vol.
* The report reviews Eukaryotic Translation Initiation Factor
4E (eIF-4E) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Fold Gene Description change elF2 signaling E1F1AX Eukaryotic translation initiation factor
1A, -1.343 X-Linked EIF2B3 Eukaryotic translation initiation factor
2B, -1.361 subunit 3 gamma, 58kDa EIF3B Eukaryotic translation initiation factor
3, -1.385 subunit B EIF4G1 Eukaryotic translation initiation factor
4 -1.306 gamma, 1 MAP2K1 Mitogen-activated protein kinase inase 1 1.306 PPP1R15A Protein phosphatase 1, regulatory subunit 15A 1.784 RPL7L1 Ribosomal protein L7-like 1 -1.283 RPL14 Ribosomal protein L14 -1.297 RPL36 Ribosomal protein L36 -1.424 RPL36A Ribosomal protein L36a -1.400 RPS2 Ribosomal protein S2 -1.376 RPS7 Ribosomal protein S7 -1.619 RPS15 Ribosomal protein S15 -1.641 Table 4 Molecular docking of CPT to P13K (PDB ID: 1E8Y) and eIF4A (PDB ID:2G9N).
Gingras et al., "Phosphorylation of eucaryotic translation initiation factor
4B Ser422 is modulated by S6 kinases," The EMBO Journal, vol.
Blocking eukaryotic initiation factor
4F complex formation does not inhibit the mTORC1-dependent activation of protein synthesis in cardiomyocytes.
Hsu et al., "MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor
4E-bindingprotein 1-mediated inhibition of autophagy," Cancer Research, vol.
In cells deficient in nutrients or growth factors, 4E BP1 binds to the eukaryotic initiation factor
eIF4E preventing its binding to the 5'-cap mRNA or the initiation factor
This study provides evidence for the first time that SEY contains higher levels of Pyruvate Kinase, HSP70 and Elongation factor 2 and lower levels of Eukaryotic Translation Initiation Factor
5A-2 and Triosephosphafe (somerase than those found in RY.