initiation factor

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in·i·ti·a·tion fac·tor (IF),

one of several soluble proteins involved in the initiation of protein or RNA synthesis.

Farlex Partner Medical Dictionary © Farlex 2012

in·i·ti·a·tion fac·tor

(IF) (i-nish'ē-ā'shŭn fak'tŏr)

One of several soluble proteins involved in the initiation of protein or RNA synthesis.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

initiation factor (IF)

one of a group of special proteins required for the initiation of protein synthesis; promoting the correct association of RIBOSOME and mRNA. see TRANSLATION.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

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References in periodicals archive ?

Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells.

REOVIRUS INFECTION CHANGES TRANSCRIPT LEVELS OF EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (eIF4E) FAMILY MEMBERS AND eIF4E-BINDING PROTEIN (4E-BP) IN THE BLUE CRAB CALLINECTES SAPIDUS

Pathological variants in one of the five genes encoding the five subunits of eukaryotic translation initiation factor eIF2B has been implicated.

A Novel Mutation in the EIF2B4 Gene Associated with Leukoencephalopathy with Vanishing White Matter

Sonenberg, "Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells," The EMBO Journal, vol.

Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression

Tisdale, "Increased expression of phosphorylated forms of RNA-dependent protein kinase and eukaryotic initiation factor 2alpha may signal skeletal muscle atrophy in weight-losing cancer patients," British Journal of Cancer, vol.

Linking Cancer Cachexia-Induced Anabolic Resistance to Skeletal Muscle Oxidative Metabolism

Hekerman et al., "Selective inhibition of eukaryotic translation initiation factor 2[alpha] dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic [beta]-cell dysfunction and apoptosis," Journal of Biological Chemistry, vol.

Integrated Stress Response as a Therapeutic Target for CNS Injuries

* The report reviews Eukaryotic Translation Initiation Factor 4E (eIF-4E) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources

New Market Report: Eukaryotic Translation Initiation Factor 4E (eIF-4E) - Pipeline Review, H1 2016

Fold Gene Description change elF2 signaling E1F1AX Eukaryotic translation initiation factor 1A, -1.343 X-Linked EIF2B3 Eukaryotic translation initiation factor 2B, -1.361 subunit 3 gamma, 58kDa EIF3B Eukaryotic translation initiation factor 3, -1.385 subunit B EIF4G1 Eukaryotic translation initiation factor 4 -1.306 gamma, 1 MAP2K1 Mitogen-activated protein kinase inase 1 1.306 PPP1R15A Protein phosphatase 1, regulatory subunit 15A 1.784 RPL7L1 Ribosomal protein L7-like 1 -1.283 RPL14 Ribosomal protein L14 -1.297 RPL36 Ribosomal protein L36 -1.424 RPL36A Ribosomal protein L36a -1.400 RPS2 Ribosomal protein S2 -1.376 RPS7 Ribosomal protein S7 -1.619 RPS15 Ribosomal protein S15 -1.641 Table 4 Molecular docking of CPT to P13K (PDB ID: 1E8Y) and eIF4A (PDB ID:2G9N).

Cryptotanshinone deregulates unfolded protein response and eukaryotic initiation factor signaling in acute lymphoblastic leukemia cells

Gingras et al., "Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases," The EMBO Journal, vol.

mTOR signaling in protein translation regulation: implications in cancer genesis and therapeutic interventions

Blocking eukaryotic initiation factor 4F complex formation does not inhibit the mTORC1-dependent activation of protein synthesis in cardiomyocytes.

FoxO1 inhibits skeletal muscle hypertrophy through mTOR-independent mechanisms

Hsu et al., "MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-bindingprotein 1-mediated inhibition of autophagy," Cancer Research, vol.

Total 4EBP1 is elevated in liver of rats in response to low sulfur amino acid intake

In cells deficient in nutrients or growth factors, 4E BP1 binds to the eukaryotic initiation factor eIF4E preventing its binding to the 5'-cap mRNA or the initiation factor 4G (eIF4G).

Participacion de la via de senalizacion AKT/mTORC1 en la proliferacion de las celulas [beta] del pancreas

This study provides evidence for the first time that SEY contains higher levels of Pyruvate Kinase, HSP70 and Elongation factor 2 and lower levels of Eukaryotic Translation Initiation Factor 5A-2 and Triosephosphafe (somerase than those found in RY.