initiation codon


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in·i·ti·a·tion co·don

a specific mRNA sequence (usually AUG, but sometimes GUG) that is the signal for the addition of fMet-tRNA and the beginning of translation.

in·i·ti·a·tion co·don

(i-nish'ē-ā'shŭn kō'don)
A specific mRNA sequence (usually AUG, but sometimes GUG) that is the signal for the addition of fMet-tRNA and the beginning of translation.
Synonym(s): initiating codon.

initiation codon

a triplet of bases in mRNA with the sequence AUG (less commonly, GUG) that acts as a ‘start’ signal for TRANSLATION, specifying the first amino acid at the N-terminus of the POLYPEPTIDE CHAIN. see GENETIC CODE.
References in periodicals archive ?
Zhang, "The role of eIF1 in translation initiation codon selection in Caenorhabditis elegans" Genetics, vol.
Creation of AUG initiation codons by addition of uridines within cytochrome b transcripts of kinetoplastids.
An AUG initiation codon, not codon-anticodon complementarity, is required for the translation of unleadered mRNA in Eschenichia coli.
In estimating our results, we had in mind the first initiation codon, which is thought to have more favorable flanking sequences for initiation of protein synthesis, although use of leaky scanning mechanism could be the reason of initiation at the second AUG codon (21).
A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin.
dollfusi began with the unorthodox translation initiation codon ATA and all others use the standard ATG.
Most protein-coding genes began with ATG codon (Supplementary Table S1) except COI gene and ATP6 gene used the initiation codon GTG and ATA.