loading dose

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dose

 [dōs]
the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.
absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads.
air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens.
booster dose an amount of immunogen (vaccine, toxoid, or other antigen preparation), usually smaller than the original amount, injected at an appropriate interval after primary immunization to sustain the immune response to that immunogen.
curative dose (CD) a dose that is sufficient to restore normal health. See also median curative dose.
divided dose fractionated dose.
effective dose (ED) that quantity of a drug that will produce the effects for which it is administered. See also median effective dose.
erythema dose that amount of radiation that, when applied to the skin, causes erythema (temporary reddening).
fatal dose lethal dose.
fractionated dose a fraction of the total dose prescribed, as of chemotherapy or radiation therapy, to be given at intervals, usually during a 24-hour period.
infective dose (ID) that amount of a pathogenic agent that will cause infection in susceptible subjects. See also median infective dose and tissue culture infective dose.
lethal dose (LD) that quantity of an agent that will or may be sufficient to cause death. See also median lethal dose and minimum lethal dose.
loading dose a dose of medication, often larger than subsequent doses, administered for the purpose of establishing a therapeutic level of the medication.
maintenance dose the amount of a medication administered to maintain a desired level of the medication in the blood.
maximum tolerated dose tolerance dose.
maximum permissible dose the largest amount of ionizing radiation that one may safely receive within a specified period according to recommended limits in current radiation protection guides. The specific amounts vary with age and circumstance.
median curative dose (CD50) a dose that abolishes symptoms in 50 per cent of test subjects.
median effective dose (ED50) a dose that produces the desired effect in 50 per cent of a population.
median infective dose (ID50) that amount of pathogenic microorganisms that will produce demonstrable infection in 50 per cent of the test subjects.
median lethal dose (LD50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.
median tissue culture infective dose (TCID50) that amount of a pathogenic agent that will produce infection in 50 per cent of cell cultures inoculated.
minimum lethal dose
1. the amount of toxin that will just kill an experimental animal.
2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250-gm weight in 4 to 5 days when injected subcutaneously.
reference dose an estimate of the daily exposure to a substance for humans that is assumed to be without appreciable risk; it is calculated using the no observed adverse effect level and is more conservative than the older margin of safety.
skin dose (SD)
1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.
2. the absorbed dose in the skin.
threshold dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.
threshold erythema dose (TED) the single skin dose that will produce, in 80 per cent of those tested, a faint but definite erythema within 30 days, and in the other 20 per cent, no visible reaction.
tissue culture infective dose (TCID) that amount of a pathogenic agent that will produce infection when inoculated on tissue cultures; used with a numeric qualifier.
tolerance dose the largest quantity of an agent that may be administered without harm. Called also maximum tolerated dose.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

load·ing dose

a comparatively large dose given at the beginning of treatment to start getting the effect of a drug, especially one with slow clearance, thus requiring a long period to achieve stable blood levels without a high initial dose.
Synonym(s): initial dose
Farlex Partner Medical Dictionary © Farlex 2012

loading dose

Initial dose Pharmacology A first dose of a drug administered in excess of the maintenance dose, administered to rapidly achieve therapeutic drug levels. Cf Maintenance dose.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

load·ing dose

(lōd'ing dōs)
The first dose of a medicine, which is much larger than the following doses, to reach a therapeutic level more rapidly.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

load·ing dose

(lōd-ing' dōs)
Comparatively large dose given at beginning of treatment to start getting the effect of a drug.
Synonym(s): initial dose.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
A single dose given to three children and two successive doses given to the fourth child caused hematemesis within 24 hours of the initial dose, prompting parents to call their pediatricians, Dr.
Willmar Schwabe Pharmaceuticals, Karlsruhe, Germany) in an initial daily dose of 900 mg/day, or paroxetine (Paxil) in an initial dose of 20 mg/day.
One woman in the high-dose group presented to the emergency room approximately 8 hours after receiving the initial dose and was diagnosed with an incomplete abortion and dehydration.
In both groups, managing physicians had the option to treat patients with an initial dose of intravenous antibiotic, if clinically indicated (400 mg of ciprofloxacin in the ciprofloxacin group or 1 gram of ceftriaxone in the TMP-SMZ group).
Those who responded to the initial dose were sent home and given steriods and oral cyclosporin for six months.
A statistically significant greater percentage of ubrogepant patients (both doses) achieved pain freedom at two hours after the initial dose, compared to placebo, and a statistically significant greater percentage of ubrogepant patients achieved absence of the most bothersome migraine-associated symptoms two hours after the initial dose, compared to placebo.
Using a database of all patient visits to a weekly academic clinic during 1980-2004, the investigators analyzed all initial prednisone prescriptions and classified patients into one of two groups: those treated with an initial prednisone dosage of 5 mg/day or higher, and those treated with an initial dose lower than 5 mg/day.
Elizabeth Mechcatie, editor Drug Cost/Day* Dosage eszopiclone [$3.70 (2 mg or 2-3 mg at bedtime [Lunesta] 3 mg)] (1-2 mg for the elderly) ramelteon [$2.81] 8 mg within 30 minutes of [Rozerem] bedtime temazepam $0.14 (15 mg) 7.5-30 mg at bedtime [Restoril] [$3.75 (15 mg)] (initial dose of 7.5 mg for elderly patients) trazodone $0.07 (50 mg) 25-75 mg at bedtime [Desyrel] [$1.80 (50 mg)] zaleplon [$2.48 (5 mg)] 5-20 mg at bedtime [Sonata] [$3.05 (10 mg)] (initial dose of 5 mg for elderly patients) zolpidem [$3.23] 5-10 mg at bedtime [Ambien] (initial dose of 5 mg for elderly patients) zolpidem [price not available] 12.5 mg at bedtime extended-release (6.25 mg for the elderly) [Ambien CR] Drug What the Experts Say** eszopiclone Available in trade formulation only.
The recommended dose for palivizumab may be too low, because 40% of babies do not attain an effective serum level of 30 [micro]g/mL after the initial dose. Below this serum level, the virus can still be active.
Start with a dose that is half of the recommended initial dose, and decide when and whether to increase it.
The American College of Obstetricians and Gynecologists recommends an initial dose of 25 [micro]g of misoprostol for cervical ripening and induction.
Some of those responding received booster shots one month after the initial dose. Side effects, which included local tenderness and fever, were minimal, Fauci says.

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