inhibitory concentration


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inhibitory concentration

Abbreviation: IC
The concentration of a medication in the blood that will inhibit the replication of a specified percentage of microorganisms. The abbreviation IC is often followed by a number, e.g., 50 or 90. The IC50 of a drug to treat acquired immunodeficiency syndrome is the drug concentration that will inhibit replication of 50% of all HIV virions, and IC90 is the concentration that will inhibit 90% of the virions.
See also: concentration
References in periodicals archive ?
Serum concentration at different time points in patients with primary progressive disease and their relationship with minimum inhibitory concentration (MIC) of pyrazinamide are presented in Table II.
Table 2 Minimum inhibitory concentrations (MICs) in mg/ml and fractional inhibitory concentration indices (FICIs) of combinations of quercetin (2) and 3-0-methylquercetin (3) against Staphylococcus aureus.
Table 1 Minimum inhibitory concentrations (MICs) of 7-(2-oxohexyl)-taxodione (oxohexyl-TAX) and taxodione (TAX), compared to MIC of the reference antibiotics-oxacillin (OXA) and vancomycin (VAN).
Most nonalbicans Candida species have higher minimum inhibitory concentrations (MICs) to the azole antifungal agents, and infections they cause are often difficult to treat (3,4).
The sensitivity of microorganisms to tested samples was tested by determining the minimal inhibitory concentration (MIC).
The concentration of fluoroquinolone required for SOS-mediated discontinuation of cell replication is expressed as a peak concentration/minimum inhibitory concentration (MIC) ratio and appears to require a ratio of approximately 10:1 (50,51).
The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), the rate of kill and the pH sensitivity of the essential oil were determined by microdilution tests performed in 96-well plates.
In one laboratory study (Abstract F2050), researchers from International Health Management Associates and GlaxoSmithKline determined the minimum inhibitory concentration (MIC) of retapamulin against more than 3,700 clinical isolates of staphylococci, beta-hemolytic (BHS) and viridans streptococci (VSP), collected from patients at 17 sites across North America.
These analyses suggest that average liver concentration values are up to 57-fold above the replicon 90% inhibitory concentration ("IC90") and 113-fold above the 50% inhibitory concentration ("IC50") based on antiviral activity of VX-950 in the replicon assay.
8% had a levofloxacin minimum inhibitory concentration of 8 [micro]g/ mL or greater, which is defined as resistance.