Abbreviations 7-AAD: 7-Aminoactinomycin D A5: Annexin-5 DIABLO: Direct IAP-Binding Protein with Low PI DMSO: Dimethylsulfoxide EGFR: Epidermal growth factor receptor ER: Estrogen receptor FDG: Fluorodeoxyglucose HER2: Human epidermal growth factor receptor 2 IAP: Inhibitor of apoptosis proteins IV: Intravenous NIH: National Institute PET: Positron emission tomography PR: Progesterone receptor SMAC: Second Mitochondria-derived Activator of Caspases SPECT: Single-photon emission tomography SUV: Standardized uptake values TGF-[beta]: Transforming growth factor-[beta] TNBC: Triple-negative breast cancer WHO: World Health Organization.
Zou et al., "Physiologically based pharmacokinetic and pharmacodynamic modeling of an antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer," Biopharmaceutics & Drug Disposition, vol.
Afterwards, cells were lysed and whole proteins lysates were analysed by Western blot for altered expression of X-linked inhibitor of apoptosis protein
(XIAP), baculoviral IAP repeat containing 5 (BIRC5), myeloid cell leukemia 1 (MCL1), B-cell lymphoma 2 (BCL2), and BCL2 like 1 (BCL2L1).
The inhibitor of apoptosis protein
family and its antagonists in acute leukemias.
Antibody response to the tumor-associated inhibitor of apoptosis protein
survivin in cancer patients.
Scott, "Human inhibitor of apoptosis proteins
: why XIAP is the black sheep of the family," EMBO Reports, vol.
Debiopharm has entered into a collaboration with Merck KGaA and Pfizer to evaluate Debio 1143, an oral, small molecule inhibitor of IAPs (Inhibitor of Apoptosis Proteins
), in combination with avelumab, an investigational fully human anti-PD-L1 IgG1 monoclonal antibody, in advanced or metastatic Non-Small Cell Lung Cancer (NSCLC).
Inhibitor of apoptosis proteins
: translating basic knowledge into clinical practice.
Survivin is a new human gene encoding a structurally unique inhibitor of apoptosis proteins
(IAP), apoptosis inhibitor, and plays an important role in the hyperplastic growth of tissues and tumors.
Table 1 List of various pro-apoptotic and anti-apoptotic factors involved in the sepsis Pro-apoptotic factors Anti-apoptotic factors BAX Bcl-2 Bcl-xs Bcl-xl, Bcl-Al BIM, PUMA, NOXA Inhibitor of apoptosis proteins
FAS ligand Mcl-1 Tumour necrosis factor- a Ras factor- a BID, BAK Apoptosis-inducing factor p53 BAX=Bcl-2-associated X protein, Bcl=B cell lymphoma, BIM=Bcl-2-interacting moderator of cell death, PUMA=p53- upregulated modulator of apoptosis, NOXA=phorbol-12 myristate-l-acetate-induced protein, FAS=cell surface Fas receptor also known as CD95L, Mcl=M cell lymphoma, Ras=rat sarcoma, BID=BH3 interacting death domain, BAK=Bcl-2 homologous antagonist killer.
ARTS interferes with molecules called inhibitor of apoptosis proteins
(IAPs), which prevent cells from killing themselves.
TL32711 is a synthetic, small molecule peptidomimetic of SMAC (an endogenous regulator of apoptotic cell death) that selectively antagonises multiple Inhibitor of Apoptosis Proteins