inhibitor of apoptosis protein


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inhibitor of apoptosis protein (IAP)

any of a class of proteins that play a regulatory role in apoptosis in many species by inhibiting caspase activity, which in turn blocks apoptosis. Such proteins are also expressed abnormally in many tumors.
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References in periodicals archive ?
KIAP, a novel member of the inhibitor of apoptosis protein family.
Antibody response to the tumor-associated inhibitor of apoptosis protein survivin in cancer patients.
Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin and Hodgkin lymphomas.
TL32711 is a synthetic, small molecule peptidomimetic of SMAC (an endogenous regulator of apoptotic cell death) that selectively antagonises multiple Inhibitor of Apoptosis Proteins (IAPs).
Birinapant (formerly TL32711) is a small molecule peptidomimetic of Smac (Second mitochondrial-derived activator of caspases), an endogenous regulator of apoptotic cell death that selectively antagonizes multiple Inhibitor of Apoptosis Proteins (IAPs).
Birinapant (formerly TL32711) is a small molecule peptidomimetic of Smac (Second mitochondrial-derived activator of caspases) an endogenous regulator of apoptotic cell death that selectively antagonizes multiple Inhibitor of Apoptosis Proteins (IAPs).
TL32711 is a SMAC mimetic that neutralizes the activity of inhibitor of apoptosis proteins (IAPs) that block tumor cell death.
The ability of TL32711 to antagonize Inhibitor of Apoptosis Proteins in a selective manner represents a new broadly applicable approach to treat cancers that are normally resistant to therapies.

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