migration-inhibitory factor

(redirected from inhibition factor)

mi·gra·tion-in·hib·i·tor·y fac·tor (MIF),

a soluble, nondialyzable substance that is produced by sensitized lymphocytes (that is, lymphocytes from a sensitized animal) when exposed to the specific antigen, and that causes adherence and inhibition of migration of macrophages.
Synonym(s): inhibition factor
References in periodicals archive ?
Some of these defector molecules, migration inhibition factor (MIF) a lymphokine, inhibit the migration of macrophages in the same culture medium [11].
However, it showed high urinary iodide, suggesting the high iodine uptake could easily have upset the inhibition factor of the perchlorate.
When Mimivirus was used as an antigen in a migration inhibition factor assay, sero-conversion was found in patients with both community- and hospital-acquired pneumonia.
Although the typical morphologic traits of Mimivirus make its confusion with ameba organelles unlikely (Figure), positive serum samples tested on noninfected intact amebas suspended in PBS by using the same migration inhibition factor protocol did not show any reactivity.
A second is to achieve expression of a combination of more than one such human complement inhibition factor to obtain more extensive protection against the various inflammatory proteins of the complement cascade.
Normally, the complement system is held in check by complement inhibition factors.
17, 1996--Human Genome Sciences (NASDAQ: HGSI) announced today the issuance of US Patent 5,556,767 entitled Inflammatory Protein Gamma, renamed Macrophage Colony Inhibition Factor.
Claimed in this patent are both the gene encoding this novel human protein, and the use of the gene for the production of the Macrophage Colony Inhibition Factor Protein.
The Company's initial priorities are biofilm inhibition factors and anti-fungal drugs; and technology which enhances the production of fungally-derived drugs and other metabolites.
It is particularly suited for subsequent nucleic acid amplification because the extraction method yields ultra pure nucleic acid therewith overcoming the problem of inhibition factors.