inhibin


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Related to inhibin: GnRH

in·hib·in

(in-hib'in),
One of several proteins that participate in differentiation and growth. Two glycoproteins, inhibin A and inhibin B, are secreted by Sertoli cells in the testis and granulosa cells in the ovary, inhibiting FSH secretion by direct action on the pituitary.
[inhibit + -in]

inhibin

(ĭn-hĭb′ĭn)
n.
A peptide hormone secreted by the follicular cells of the ovary and the Sertoli cells of the testis that inhibits secretion of follicle-stimulating hormone from the anterior pituitary.

inhibin

A hormone that inhibits secretion of the FOLLICLE-STIMULATING HORMONE (FSH) by the pituitary gland. It is produced by the Sertoli cells of the seminiferous tubules in the male and by the granulosa cells of the ovaries in females.
References in periodicals archive ?
Inhibins are also involved in the regulation of folliculogenesis through autocrine and/or paracrine control [9], therefore, it has been predicted that immunoneutralization of endogenous inhibin would lead to an increase in pituitary FSH secretion which could promote ovarian hyperstimulation, resulting in an increased ovulation rate.
Some serum markers in second trimester of pregnancy are useful in determining risk of developmental and chromosomal anomalies; these include Alpha fetoprotein (AFP), Human chorionic gonadotrophin (HCG), Unconjugated estriol (uE3) and Inhibin A (Inh-A).
Inhibin B and AMH concentrations were substantially below the expected values with regard to patient's age and PCOS diagnosis.
Hence, an active lifelong follow-up is recommended with clinical examination and tumor markers such as inhibin B [17].
Inhibin is the most sensitive marker of Leydig cell tumors and is expressed in virtually all cases [11].
Immunohistochemistry aids diagnosis, since the tumor shows positivity for the sex-cord markers calretinin, inhibin, CD99, Wilms' tumor protein 1, and melanoma antigen recognized by T cells (MART-1), for the epithelial markers pan-cytokeratin and epithelial membrane antigen (EMA), for the myeloid markers smooth muscle actin (SMA), desmin, and histone deacetylase 8, and for a range of other markers such as CD10, estrogen receptors, progesterone receptors, S100, and CD117, characterizing the varying phenotypes of this rare form of tumor [8].
However, both neoplasms may show architectural overlap including sheets and trabeculae of cells exhibiting inhibin positivity [1].
Serum testosterone, anti-Mullerian hormone (AMH), and inhibin B were measured using ELISA according to the manufacturer's instructions of the kits (Biomatik, USA).
Inhibin A (INHA) is a glycoprotein hormone which has a role in regulating the synthesis and secretion of pituitary follicle-stimulating hormone.
As a woman ages and her egg supply declines, cells in the ovary secrete lower amounts of inhibin B and anti-Mllerian hormone, substances considered to be indicators of ovarian reserve.