are also involved in the regulation of folliculogenesis through autocrine and/or paracrine control , therefore, it has been predicted that immunoneutralization of endogenous inhibin
would lead to an increase in pituitary FSH secretion which could promote ovarian hyperstimulation, resulting in an increased ovulation rate.
Some serum markers in second trimester of pregnancy are useful in determining risk of developmental and chromosomal anomalies; these include Alpha fetoprotein (AFP), Human chorionic gonadotrophin (HCG), Unconjugated estriol (uE3) and Inhibin
B and AMH concentrations were substantially below the expected values with regard to patient's age and PCOS diagnosis.
Polymorphisms in inhibin
[alpha] gene promoter associated with male infertility.
Hence, an active lifelong follow-up is recommended with clinical examination and tumor markers such as inhibin
is the most sensitive marker of Leydig cell tumors and is expressed in virtually all cases .
Immunohistochemistry aids diagnosis, since the tumor shows positivity for the sex-cord markers calretinin, inhibin
, CD99, Wilms' tumor protein 1, and melanoma antigen recognized by T cells (MART-1), for the epithelial markers pan-cytokeratin and epithelial membrane antigen (EMA), for the myeloid markers smooth muscle actin (SMA), desmin, and histone deacetylase 8, and for a range of other markers such as CD10, estrogen receptors, progesterone receptors, S100, and CD117, characterizing the varying phenotypes of this rare form of tumor .
However, both neoplasms may show architectural overlap including sheets and trabeculae of cells exhibiting inhibin
Serum testosterone, anti-Mullerian hormone (AMH), and inhibin
B were measured using ELISA according to the manufacturer's instructions of the kits (Biomatik, USA).
GDF11, GDF8, inhibin
and Bone Morphogenetic Protein 7 (BMP7).
A (INHA) is a glycoprotein hormone which has a role in regulating the synthesis and secretion of pituitary follicle-stimulating hormone.