inhaled insulin


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inhaled insulin

Insulin given by inspiration, with the use of an inhaler. It may be composed of liquid droplets or a dry powder. One inhaled insulin product was removed from use in 2008 because of its adverse effects on the lungs.
See also: insulin
References in periodicals archive ?
We believe our inhaled insulin product is state-of-the-art and well-differentiated from powder based, non-electronic technology.
John Patton, who has over 25 years of experience developing inhaled insulin and other inhaled therapies.
Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for type 2 diabetes: a multicentre randomized trial.
Efficacy: We can safely assume by virtue of regulatory approvals that inhaled insulin is efficacious for the approved indications.
That's because little more than 10% of the inhaled insulin reaches the alveoli in the lungs where it is absorbed into the bloodstream.
Extensive research has been done to ameliorate the airway hyper-responsiveness mediated by inhaled insulin.
At a meeting of the FDA's Endocrinologic and Metabolic Drugs Advisory Committee, panelists voted 13-1 that the safety and efficacy data for the inhaled insulin, delivered with an inhaler, supported approval for treatment of adults with type 1 diabetes; they voted 14-0 that the data supported approval for treatment of adults with type 2 diabetes.
Garg, a professor of Medicine and Pediatrics at the University of Colorado Denver, says that the results of a 2-year Phase 3 trial conducted in 385 patients suggest that AIR inhaled insulin was inferior to SC insulin in its ability to maintain optimal blood glucose levels over time, based on measurements of glycosylated hemoglobin (HbA1c).
Pfizer's research on inhaled insulin, demonstrated a paradoxic increase in absorption of the medication in smokers, which led to increased blood levels of insulin (hyperinsulinemia).
If inhaled insulin had come to market in the mid-1990s, when we had only two classes of oral agents (metformin had just been introduced), this would have been a clear alternative to injectable insulin for those type 2 diabetes patients who were already on insulin or needed to be transferred to it.
Inhaled insulin should not be used in patients with chronic, unstable, or poorly controlled lung disease; smokers; or those who quit smoking <6 months earlier.