pulmonary delivery system

(redirected from inhalation delivery system)

pulmonary delivery system

A system designed for noninvasive, systemic delivery of therapeutic macromolecules (e.g., insulin, tobramycin, leuprolide, dronabinol, PTH) via alveolar absorption.

Pros
Pulmonary route offers the highest bioavailability of any noninvasive route and facilitates more rapid drug absorption in the circulation compared with subcutaneous injection.
 
Cons
Administration of insulin, the pilot for the pulmonary delivery platform, resulted in inconsistent serum levels. It proved too expensive for the market.
References in periodicals archive ?
Rodgers D GC, Paul G, Moore S, Meecham K, Jordan S, Efficacy of an inhaled PFE4 inhibitor, GSK256066, delivered by a novel dry powder pre-clinical inhalation delivery system in the acute cigarette smoke induced pulmonary inflammation model.
a wholly-owned subsidiary of United Therapeutics, to develop their pulmonary arterial hypertension (PAH) drug treprostinil in Aradigm's AERx Essence inhalation delivery system.
AERx Essence inhalation delivery system is a palm-size, easy to use inhalation device that is expected to deliver medication to the patient in 2 to 4 breaths.
This particular IDE approval allows Ohmeda to provide the nitric oxide inhalation delivery system to qualified holders of Investigational New Drug Applications for nitric oxide inhalation, which are granted by the FDA to investigators to conduct clinical research.
Inhalation delivery systems for drug products can vary in both design and mode of operation, and these characteristics may be unique to a particular drug product.
These particles have distinct physical characteristics with several potential advantages over other inhalation delivery systems.