pulmonary delivery system

(redirected from inhalation delivery system)

pulmonary delivery system

A system designed for noninvasive, systemic delivery of therapeutic macromolecules (e.g., insulin, tobramycin, leuprolide, dronabinol, PTH) via alveolar absorption.

Pros
Pulmonary route offers the highest bioavailability of any noninvasive route and facilitates more rapid drug absorption in the circulation compared with subcutaneous injection.
 
Cons
Administration of insulin, the pilot for the pulmonary delivery platform, resulted in inconsistent serum levels. It proved too expensive for the market.
References in periodicals archive ?
(15.) Rodgers D GC, Paul G, Moore S, Meecham K, Jordan S, Efficacy of an inhaled PFE4 inhibitor, GSK256066, delivered by a novel dry powder pre-clinical inhalation delivery system in the acute cigarette smoke induced pulmonary inflammation model.
Cross, "Asthma inhalation delivery systems: the patient's viewpoint," Journal of Aerosol Medicine, vol.