With metformin treatment for 4 weeks, the IR of the high-fat diet induced obese rats was obviously improved, manifested as enhanced glucose infusion rate
, reduced serum TG and serum insulin levels, and down-regulated mRNA expression of PEPCK, G-6-Pase (Table 2, Figure 1).
Table 3 summarizes insulin infusion rates
and steady state plasma insulin and glucose levels, as well as the GIRs needed to maintain isoglycemia, with results consistent with previous findings and in addition showing that tesaglitazar treatment completely restored insulin's ability to maximally stimulate GIR (responsiveness).
The different insulin infusion rate
used in other studies (3,7), will not affect the insulin sensitivity values but changes in the time taken to achieve a steady state plasma insulin levels occur.
(35.) Helene Russo & Francoise Bressolle, Pharmacodynamics and Pharmacokinetics of Thiopental 35 CLINICAL PHARMACOKINETICS 95, 107 (1998) (describing the differences on dosage requirements as a function of infusion rate
The infusion rate
for animals weighing 72.0 and 72.5 kg was 17.0 ml/min, while the rate for animals weighing 83 to 97 kg was 19.0 ml/min.
* Use the lowest dose necessary at the slowest infusion rate
In addition, the usual infusion rate
for my patients was five to 15 minutes, depending on their tolerance.
Recommendation: Insulin infusions may be given via the same line as other compatible medications provided the infusion rate
The desired BrAC exposure is achieved by administering alcohol according to a specific dosage and rate (i.e., infusion rate
profile) (Figure 1B) that is pre-computed for each individual by estimating physiological parameters that include his or her specific alcohol elimination rate (AER).
(8) This may be prevented by a more gradual decrease of the infusion rate
(such as halving the rate for two to four hours before stopping), with monitoring of blood glucose levels.
The statement, entitled, "Peripherally Inserted Central Catheter Lines or Ports for Power Injectors" reads: "The ASRT recognizes the use of power injectors with a Peripherally Inserted Central Catheter (PICC) line or ports for power injectors is within the scope of practice for radiologic technologists with the appropriate clinical and didactic education and when an FDA-approved PICC line catheter or port specifically for power injectors is used and manufacturer guidelines regarding infusion rate
and pressure are followed, where state and/or institutional policy permits."
This involved over 40 variations of bag design combined with laboratory testing to achieve the optimum balance between infusion rate
, filtration and 'drip time'.