In vitro studies in human and mouse cell lines as well as knockout mice reveal the activation of ATF2 in several inflammatory diseases including obesity, hepatitis,
inflammatory pain, and allergic asthma [80, 81].
"There are efficacious treatments for
inflammatory pain, such as corticosteroids and non-steroidal anti-inflammatory drugs," said Bhattacharjee.
EA in models of
inflammatory pain by injection of Freund's adjuvant [16, 18, 33] or carrageenan [39], neuropathic pain by section between S1 and S2 [28, 30], and through the tail flick test in mice to verify the effectiveness of different frequencies of EA [40].
In conclusion, ABC transporters appear to play an important role in
inflammatory pain and in analgesia (opioids or nonsteroidal anti-inflammatory drugs).
8 September 2011 - Israeli BioLineRx Ltd (TLV:BLRX) said yesterday it has sealed a worldwide, exclusive licence deal with Ramot at Tel Aviv University Ltd, the technology transfer company of Tel Aviv University, for the development and commercialisation of BL-7050, an orally-available treatment for neuropathic and
inflammatory pain.
The effectiveness of AXyl in
inflammatory pain together with previous evidences of that xylopine inhibits platelet aggregation (Chen et al.
The team, funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and working at UCL (University College London), has claimed that the mechanism is so different from what has already been discovered about the biology underpinning pain that it could be the Achilles heel of chronic
inflammatory pain, which is notoriously difficult to treat.
Namely, chronically administered MnL4 may prevent tissue degenerative alterations induced by the oxidative stress and reduce a persistent
inflammatory pain via a direct antioxidant mechanism; while in acute administration, it may decrease the nociceptive nervous fiber activation induced by the local production of ROS [28, 50].
It comes in two forms:
inflammatory pain and neuropathic pain.
*
Inflammatory pain, which results from activation of the immune system in response to injury or infection.
More importantly, by working at the site of the original injury, this peripherally-acting fatty acid helps break the
inflammatory pain cycle.
(30) In a rat model of sciatic nerve pain and
inflammatory pain, oral treatment with CBD (2.5-20 mg/kg for neuropathic sciatic pain and 20 mg/kg for
inflammatory pain) or intraplantar injection from a week to 14 days post-injury reduced the sensitization to painful stimuli.