inflammatory fibroid polyp

inflammatory fibroid polyp (GI tract)

An intraluminal projection of mucosa formed from non-neoplastic stromal and epithelial elements admixed with inflammatory cells.

A non-neoplastic, reactive, recurrent, often bilateral “tumour” formed in response to infection, allergy, mucoviscidosis.

Allergy, vasomotor rhinitis, infection, aspirin, cystic fibrosis, secondary changes caused by infarction, infection, vascular proliferation.

Any of a number of often bizarre polyps and/or bridges of mucosa, which when single may mimic malignancy and when multiple mimic a polyposis syndrome; Ips may arise in a background of inflammatory bowel disease—Crohn’s disease, ulcerative colitis, amoebic colitis, bacterial dysentery, and chronic schistosomiasis—and are benign, nonspecific sequelae of inflammation of the intestinal mucosa.
Clinical findings
Ips are rarely symptomatic, but pain, obstruction and, if large, intussusception may occur.  

Inflammatory fibrous polyp stages
Ÿ Nodular—Immature fibroblasts, loose myxoid stroma.
Ÿ Fibrovascular—Concentric mature fibroblasts, endothelial proliferation, eosinophil infiltration.
ŸSclerotic/oedematous—Collagenisation or vascular compromise.
References in periodicals archive ?
Inflammatory fibroid polyp (IFP) is a group of rare benign mesenchymal tumors throughout the gastrointestinal tract.
The morphological picture of a cellular and atypical spindle cell tumor raised the differentials of GIST, smooth muscle tumor, desmoid tumor, fibrosarcoma, and inflammatory fibroid polyp.
Inflammatory fibroid polyp exhibits a submucosal proliferation of bland spindle-shaped cells, prominent vessels, and inflammatory cells "typically" rich in eosinophils dispersed in a fibromyxoid stroma.
Various cases have been reported due to underlying adenoma, lipoma, primary malignant neoplasm, lymphoma, metastatic lesion, Meckel's diverticulum, Crohn's disease, adhesion, Peutz-Jeghers polyp, inflammatory fibroid polyp, enteric tube, or congenital band.
However, the prominence of eosinophils and condensation of spindled cells around vessels may be helpful features that favor a diagnosis of an inflammatory fibroid polyp.
35) The differential diagnosis includes schwannoma, myxoma, inflammatory fibroid polyp, and GIST.
The inflammatory fibroid polyp (IFP) is a localized lesion of the gastrointestinal tract constituted by a proliferation of spindle, stellate, or epithelioid mesenchymal cells infiltrated by a variable number of inflammatory cells, including lymphocytes, eosinophils, and mast cells, with a vascularized stroma with collagen fibers.
These include leiomyoma, leiomyosarcoma, schwannoma, fibromatosis, inflammatory myofibroblastic tumor, inflammatory fibroid polyp, and melanoma.
They may manifest as abnormal intestinal soft tissue reactive changes (eg, inflammatory fibroid polyp [IFP]), exuberant prolapse-induced changes (eg, colitis cystica profunda), unusual-appearing cellular changes (eg, malakoplakia, bizarre stromal cells [BSC], or benign signet ring cells), and morphologic findings made unusual by their location (heterotopias).
Theories include an origin from dendritic interstitial cells, follicular dendritic cells, an early stage of inflammatory fibroid polyp, or the result of local inflammation resulting in the formation of scar tissue.
Inflammatory Myofibroblastic tumours (inflammatory pseudotumour) of the gastrointestinal tract: How closely are they related to inflammatory fibroid polyps.

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