inflammatory fibroid polyp

inflammatory fibroid polyp (GI tract)

An intraluminal projection of mucosa formed from non-neoplastic stromal and epithelial elements admixed with inflammatory cells.

A non-neoplastic, reactive, recurrent, often bilateral “tumour” formed in response to infection, allergy, mucoviscidosis.

Allergy, vasomotor rhinitis, infection, aspirin, cystic fibrosis, secondary changes caused by infarction, infection, vascular proliferation.

Any of a number of often bizarre polyps and/or bridges of mucosa, which when single may mimic malignancy and when multiple mimic a polyposis syndrome; Ips may arise in a background of inflammatory bowel disease—Crohn’s disease, ulcerative colitis, amoebic colitis, bacterial dysentery, and chronic schistosomiasis—and are benign, nonspecific sequelae of inflammation of the intestinal mucosa.
Clinical findings
Ips are rarely symptomatic, but pain, obstruction and, if large, intussusception may occur.  

Inflammatory fibrous polyp stages
Ÿ Nodular—Immature fibroblasts, loose myxoid stroma.
Ÿ Fibrovascular—Concentric mature fibroblasts, endothelial proliferation, eosinophil infiltration.
ŸSclerotic/oedematous—Collagenisation or vascular compromise.
References in periodicals archive ?
The inflammatory fibroid polyp (IFP) is a localized lesion of the gastrointestinal tract constituted by a proliferation of spindle, stellate, or epithelioid mesenchymal cells infiltrated by a variable number of inflammatory cells, including lymphocytes, eosinophils, and mast cells, with a vascularized stroma with collagen fibers.
Inflammatory fibroid polyp must be therefore considered in the differential diagnosis of mesenchymal lesions of the gallbladder, and PDGFRA analysis is a helpful tool for this purpose.
Inflammatory fibroid polyps are mesenchymal lesions occurring throughout the digestive tract, especially in the stomach and small intestine; (2) to our knowledge, only 1 case has been reported so far in the gallbladder.
These include leiomyoma, leiomyosarcoma, schwannoma, fibromatosis, inflammatory myofibroblastic tumor, inflammatory fibroid polyp, and melanoma.
Inflammatory fibroid polyp is a submucosal mesenchymal tumor that has a predilection for the stomach (particularly, the antrum) and small intestine.
Inflammatory fibroid polyps of the gastrointestinal tract: clinical, pathologic, and molecular characteristics.
They may manifest as abnormal intestinal soft tissue reactive changes (eg, inflammatory fibroid polyp [IFP]), exuberant prolapse-induced changes (eg, colitis cystica profunda), unusual-appearing cellular changes (eg, malakoplakia, bizarre stromal cells [BSC], or benign signet ring cells), and morphologic findings made unusual by their location (heterotopias).
Inflammatory fibroid polyp is a rare mesenchymal pseudoneoplasm of the digestive system with unclear histogenesis.
Theories include an origin from dendritic interstitial cells, follicular dendritic cells, an early stage of inflammatory fibroid polyp, or the result of local inflammation resulting in the formation of scar tissue.
The differential diagnosis of benign fibroblastic polyps includes other spindle cell proliferations that may present as mucosal polyps within the gastrointestinal tract, including inflammatory fibroid polyps (Vanek tumor), gastrointestinal stromal tumor, schwannoma, ganglioneuroma, inflammatory cloacogenic polyp, prolapsing mucosal polyp, smooth muscle tumors, and the recently described intestinal perineurioma.
Inflammatory fibroid polyps (IFPs) were originally described in 1949 by Vanek (20) under the name gastric submucosal granulomas with eosinophilic infiltration, which was simplified to Vanek tumors, a term that persists in the clinical literature.
Inflammatory fibroid polyps harbor mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene.

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