inflammatory bowel disease


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inflammatory bowel disease

 
any of various inflammatory diseases of the bowel whose etiology is unknown, including crohn's disease and ulcerative colitis.

inflammatory bowel disease (IBD),

general term for Crohn disease and ulcerative colitis, chronic disorders of the small and large intestine, of unknown cause, with conspicuous inflammatory features and distinctive but overlapping signs and symptoms.

inflammatory bowel disease

n. Abbr. IBD
Any of several chronic disorders of the gastrointestinal tract, especially Crohn's disease and ulcerative colitis, characterized by inflammation and ulceration of the intestine and resulting in abdominal cramping and diarrhea.

inflammatory bowel disease

A general term for the symptoms associated with specific types of inflammation of the large intestine, including Crohn's disease–CD, ulcerative colitis–UC as well as idiopathic inflammatory bowel disease, a diagnosis of exclusion that clinically and pathologically mimics and/or overlaps CD and UC Heredity First-degree relatives of Pts with CD and UC have an 8- to 10-fold ↑ risk of developing the same form of colitis DiffDx Ischemia, radiation, uremia, cytotoxic drugs, heavy metal intoxication; IBD Pts often have ≥ 2 of following: Visible abdominal distension, relief of pain upon defecation, looser and more frequent bowel movements when the pain occurs; ♂:♀ ratio, 2:1; more common in Jews; IBD is associated with mucocutaneous disease–pyoderma gangrenosa, erythema nodosum, oral ulcers, annular erythema, vascular thromboses, epidermolysis bullosa, ocular disease–uveitis, iridocyclitis, hepatopathy–CAH, cirrhosis, sclerosing cholangitis, arthropathy–ankylosing spondylitis. Cf Irritable bowel syndrome Treatment Corticosteroids—or corticotropin–favored by some clinicians, aminosalicylates–sulfasalazine and 5-aminosalicylic acid, immunomodulatory agents–azathioprine, mercaptopurine, cyclosporine, MTX, metronidazole, antibiotics and nutritional support–both more effective in Crohn's disease, resulting in ↓ Sx, ↓ inflammatory sequelae, improved nutritional status.
Inflammatory bowel disease  
Clinical  Ulcerative colitis Crohn's disease
Rectal bleeding  Common  Rare
Abdominal mass  Rare  10-15%
Abdominal pain  Left-sided  Right-sided
Abnormal endoscopy  95%  < 50%
Perforation  12%  4%
Colon carcinoma  5-10%  Rare
Response to steroids  75%  25%
Surgical outcome Excellent  Fair
Rectal involvement  > 95%  !0%
Radiology
Ileal involvement  Rare  Usual
Cross-hatched ulcers  Rare  Occasional
Thumbprinting  Absent  Common
Fissuring  Absent  Common
Skip areas  Absent  Common
Strictures  Absent  Common
Pathology
Distribution  Diffuse  Focal
   Superficial  Transmural
Mucosal atrophy Regeneration  Marked Minimal
Hyperemia  Often marked  Minimal
Crypt abscess  Common  Rare
Cytoplasmic mucin  Decreased  Intact
Lymphoid aggregates  Rare  Common
Lymph nodes  Reactive hyperplasia  -----
Edema  Minimal Marked
Granulomas  Absent  60%  

in·flam·ma·to·ry bow·el dis·ease

(IBD) (in-flam'ă-tōr-ē bow'ĕl di-zēz')
General term for Crohn disease and ulcerative colitis, chronic disorders of the small and large intestine, autoimmune, with conspicuous inflammatory features and distinctive but overlapping signs and symptoms.

Inflammatory bowel disease (IBD)

Ulcerative colitis or Crohn's colitis; chronic conditions characterized by periods of diarrhea, bloating, abdominal cramps, and pain, sometimes accompanied by weight loss and malnutrition because of the inability to absorb nutrients.
References in periodicals archive ?
Mach, "Inflammatory bowel disease: epidemiology, pathology and risk factors for hypercoagulability," World Journal of Gastroenterology, vol.
Gunther et al., "Virtual chromoendoscopy for prediction of severity and disease extent in patients with inflammatory bowel disease: a randomized controlled study," Inflammatory Bowel Diseases, vol.
The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study.
Inflammatory bowel disease is rare pathology in pediatric age group and somewhat underdiagnosed entity in our region.9,10 Pediatric IBD is separate entity in its presentation, location of disease and response to treatment.
Inflammatory bowel disease is hard to treat even with strong anti-inflammatory drugs such as steroids, so talk therapy may not be strong enough.
H1N1 vaccines in a large observational cohort of patients with inflammatory bowel disease treated with immunomodulators and biological therapy.
Association of inflammatory bowel disease with asthma risk: a nationwide cohort study.
The etiology and pathogenesis of inflammatory bowel disease, including both CD and UC, still remain unknown but are thought to involve a combination of genetic susceptibility, immunity, and disturbances in host responses to intestinal flora [18].
Conclusion: The retrospective case series represents results from a developing country with low prevalence of inflammatory bowel disease and hence limited experience.
When the re-education of T cells in the gut gets disrupted this can lead to inflammatory bowel diseases, as well as other health conditions, like cardiovascular disease, obesity, diabetes, and cancer.
"There is considerable evidence that dietary prebiotics modulate the gastrointestinal microbiota with therapeutic applications to conditions, including irritable bowel syndrome, inflammatory bowel disease, obesity and bone health," according to the researchers.
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease (CD) is chronic inflammatory bowel disorders in which an altered immune response and environmental triggering factors lead to chronic inflammation of the intestinal tract.

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