In order to extend its resources, Conatus is implementing a restructuring plan that includes reducing staff by approximately 40% and suspending development of its inflammasome
disease candidate, CTS-2090.
In addition to the benefits of whole food, elimination-type diets for autoimmune conditions and targeting Gl function, inflammasome
activity can be curtailed through [beta]-hydroxybutyrate, a ketone.
The NLRP3 inflammasome
is believed to drive chronic inflammation associated with the progression of many neurodegenerative diseases, including Parkinson's Disease.
Background: The nucleotide-binding and oligomerization domain-like receptor protein 3 (NLRP3) inflammasome
composed of NLRP3, apoptosis-associated speck-like protein containing CARD (ASC), and caspase-1 is engaged in the inflammatory response of many kidney diseases and can be activated by purinergic 2X7 receptor (P2X7R).
"We found a key immune system target, called the NLRP3 inflammasome
, lights up in Parkinson's patients, with signals found in the brain and even in the blood," Woodruff said.
Recently, the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
complex (including NOD-like receptor NLRP3, the adaptor molecule apoptosis-associated speck-like protein containing a caspase-recruitment domain, and the effector molecule procaspase-1) play a critical role in the pathogenesis of neuropathic pain (2, 5).
Innate immune responses are induced through interaction with toll-like receptors and inflammasome
activation initially and subsequently through adaptive immune activation.
These promote the formation of the NLRP3 inflammasome
within activated microglia.
In these subjects, the researchers found genetic evidence of the involvement of a so-called inflammasome
The NLRP3 inflammasome
is a multiprotein complex that recognizes various pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
The Activation of the NLRP3 Inflammasome
by a Mechanism Involving the RIP1-RIP3 Signaling Pathway
In humans, NLRP1 has the ability to activate caspase-1 by interacting directly with procaspase-1 or by recruiting adaptor protein ASC and then recruiting procaspase-1 to form a complex known as inflammasome