infective dose


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Related to infective dose: median infective dose

dose

 [dōs]
the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.
absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads.
air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens.
booster dose an amount of immunogen (vaccine, toxoid, or other antigen preparation), usually smaller than the original amount, injected at an appropriate interval after primary immunization to sustain the immune response to that immunogen.
curative dose (CD) a dose that is sufficient to restore normal health. See also median curative dose.
divided dose fractionated dose.
effective dose (ED) that quantity of a drug that will produce the effects for which it is administered. See also median effective dose.
erythema dose that amount of radiation that, when applied to the skin, causes erythema (temporary reddening).
fatal dose lethal dose.
fractionated dose a fraction of the total dose prescribed, as of chemotherapy or radiation therapy, to be given at intervals, usually during a 24-hour period.
infective dose (ID) that amount of a pathogenic agent that will cause infection in susceptible subjects. See also median infective dose and tissue culture infective dose.
lethal dose (LD) that quantity of an agent that will or may be sufficient to cause death. See also median lethal dose and minimum lethal dose.
loading dose a dose of medication, often larger than subsequent doses, administered for the purpose of establishing a therapeutic level of the medication.
maintenance dose the amount of a medication administered to maintain a desired level of the medication in the blood.
maximum tolerated dose tolerance dose.
maximum permissible dose the largest amount of ionizing radiation that one may safely receive within a specified period according to recommended limits in current radiation protection guides. The specific amounts vary with age and circumstance.
median curative dose (CD50) a dose that abolishes symptoms in 50 per cent of test subjects.
median effective dose (ED50) a dose that produces the desired effect in 50 per cent of a population.
median infective dose (ID50) that amount of pathogenic microorganisms that will produce demonstrable infection in 50 per cent of the test subjects.
median lethal dose (LD50) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.
median tissue culture infective dose (TCID50) that amount of a pathogenic agent that will produce infection in 50 per cent of cell cultures inoculated.
minimum lethal dose
1. the amount of toxin that will just kill an experimental animal.
2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250-gm weight in 4 to 5 days when injected subcutaneously.
reference dose an estimate of the daily exposure to a substance for humans that is assumed to be without appreciable risk; it is calculated using the no observed adverse effect level and is more conservative than the older margin of safety.
skin dose (SD)
1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.
2. the absorbed dose in the skin.
threshold dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.
threshold erythema dose (TED) the single skin dose that will produce, in 80 per cent of those tested, a faint but definite erythema within 30 days, and in the other 20 per cent, no visible reaction.
tissue culture infective dose (TCID) that amount of a pathogenic agent that will produce infection when inoculated on tissue cultures; used with a numeric qualifier.
tolerance dose the largest quantity of an agent that may be administered without harm. Called also maximum tolerated dose.

infective dose (ID),

that quantity of a pathogen (measured in number of organisms) that is necessary to cause infection in a susceptible host.

in·fec·tive dose

(in-fek'tiv dōs)
The number of organisms necessary to produce either an infection or an immunologic response in a host.
Compare: minimal infecting dose
References in periodicals archive ?
First 4 Volume equivalent Volume equivalent 0/4 4 300 300 4/4 Second 4 Volume equivalent Volume equivalent 0/4 4 300 150 0/4 * All animals were challenged with a previously determined lethal dose of [10.sup.4] 50% tissue culture infective dose of Lassa virus (strain Josiah) via intramuscular injection.
Biological titration (Mean tissue culture infective dose: TCID50) The biological titer of the virus was determined by inoculating on to monolayer of BHK-21 cell line in 96 well flat bottom cell culture plates.
FMD virus type "A" serotype showed 106.0 +- 0.2units of infectivity titer (Tissue culture infective dose 50-TCID50) in the stationary monolayer of BHK-21 cells in roux flask (75cm2),107.2+- 0.1units of TCID50 in roller bottles (490cm2) and 108.2 +- 0.05units of TCID50 on 0.2 g of micro-carriers suspending in 200 ml of GMEM growth medium in stirring bottle (Figure 4).
Samples were then centrifuged at 3,500 rpm for 5 min, and 0.1 mL of supernatant was titrated in chicken embryo fibroblast cells to determine the median tissue culture infective dose ([TCID.sub.50]); virus growth was determined by observing the cytopathic effect.
To determine the pathogenicity of these viruses in a mammalian host, we inoculated BALB/c mice intranasally with a 106 median egg infective dose for each virus.
In a 96-well plate, 2-fold serially diluted serum samples beginning at 1:10 were incubated with 200 median (50%) tissue culture infective doses of pseudovirus at the final volume of 100 [micro]L at 37[degrees]C for 1 hour; then the mixture was added to the culture of MDCK cells.
In brief, we seeded the soil samples with 1-56 infectious units of contaminated feces; 1 infectious unit was defined as 1 g feces from an SPF duck mixed with 1 x [10.sup.7.8] 50% egg infective dose of HPAI virus (H5N1) particles.
The pathogenicity of DRV-TH11 was tested by infecting 10-day-old Pekin ducks subcutaneously at a dose of 4 x [10.sup.4.5] 50% tissue culture infective dose. Experimental infection caused death on day 3 after infection.
The viral titer measured in nasopharyngeal washes culminates on approximately day 2 or 3 after infection and can reach up to [10.sup.7] 50% tissue culture infective dose ([TCID.sub.50])/mL (13,14).
Titers of infectious virus peak during the first 24 72 h of illness ([10.sup.3]-[10.sup.7] 50% tissue culture infective dose [TCI[D.sub.50]]/mL nasopharyngeal wash) and decline within several days, with titers usually low or undetectable by day 5.