infantile fibrosarcoma

in·fan·tile fi·bro·sar·co·ma

a rapidly growing but infrequently metastasizing fibrosarcoma which usually appears on the extremities in the first year of life.
Farlex Partner Medical Dictionary © Farlex 2012
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This treatment is ideal for both pediatric and adult patients alike having solid tumors, including salivary gland tumors, infantile fibrosarcoma, and common diseases such as colon and lung cancer.
In clinical trials, larotrectinib was investigated across 29 different histologies of solid tumors including lung, thyroid, melanoma, gastrointestinal stromal tumors, colon, soft tissue sarcomas, salivary gland and infantile fibrosarcoma. Larotrectinib is an oral, highly selective TRK inhibitor that targets TRK proteins that fuel the spread and growth of the patients' cancer, regardless of where it originates in the body.
These TRK fusion proteins act as oncogenic drivers promoting cell growth and survival, leading to TRK fusion cancer, including lung, thyroid, GI cancers (colon, cholangiocarcinoma, pancreatic and appendiceal), sarcoma, CNS cancers (glioma and glioblastoma), salivary gland cancers (mammary analogue secretory carcinoma) and paediatric cancers (infantile fibrosarcoma and soft tissue sarcoma), disclosed the company.
Tumor types included 10 distinct soft tissue sarcomas, salivary gland, infantile fibrosarcoma, thyroid, lung, melanoma, colon, gastrointestinal stromal tumor, breast, bone sarcoma, cholangiocarcinoma, carcinoma of unknown primary, congenital mesoblastic nephroma, appendiceal, and pancreas cancers.
(1,17) This finding highlights the importance of the cell of origin in the oncogenesis of different entities with recurrent gene fusions, (4) a concept perhaps best illustrated by the recurrent ETV6-NTRK3 gene fusions across biologically distinct tumors of epithelial, mesenchymal, and hematopoietic differentiation (secretory carcinoma, infantile fibrosarcoma, and acute myeloid leukemia, respectively).
Previously, the ETV6-NTRK3 translocation has been described in infantile fibrosarcoma (11), congenital mesoblastic nephroma, and acute myelogenous leukaemia (2, 7, 8).
Congenital infantile fibrosarcoma (CIF) represents a malignant mesenchymal tumor accounting for 10-20% of softtissue tumors diagnosed in the early years of life [1].
Rachel, who lived with parents Anamarie and Florin and brothers Timothy, six, and Luke, four, in Buckley, battled through bouts of gruelling chemotherapy and treatment after she was diagnosed with infantile fibrosarcoma.
The lowest age in which tumour found was a 25 day old baby girl who was diagnosed of Infantile Fibrosarcoma. The oldest individual was a 70 year old man who was diagnosed to have Malignant Fibrous Histiocytoma.
The nine-month-old was thought to have been the only child in Britain with infantile fibrosarcoma when she was diagnosed at three weeks.
A biopsy of the mass revealed infantile fibrosarcoma (IF).