infantile cortical hyperostosis

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Related to infantile cortical hyperostosis: Caffey's disease


excessive growth of bony tissue. adj., adj hyperostot´ic.
frontal internal hyperostosis (hyperostosis fronta´lis inter´na) a new formation of bone tissue protruding in patches on the internal surface of the cranial bones in the frontal region, most commonly affecting women near menopause.
generalized cortical hyperostosis a hereditary disorder beginning during puberty, marked by osteosclerosis of the skull, mandible, clavicles, ribs, and diaphyses of long bones, associated with elevated blood alkaline phosphatase.
infantile cortical hyperostosis a syndrome seen in infants under six months of age, marked by fever, arthralgias, and swelling and cortical thickening of facial, trunk, and long bones. Called also Caffey's disease.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

in·fan·tile cor·ti·cal hy·per·os·to·sis

neonatal subperiosteal bone formation over many bones, especially the mandible, clavicles, and the shafts of long bones; it follows fever, usually appearing before 6 months of age and disappearing during childhood; familial cases are inherited as autosomal dominant.
Farlex Partner Medical Dictionary © Farlex 2012

Caffey disease

An autosomal dominant condition MIM 114000 characterised by fever, inflammation, swelling of affected bones (tibia, mandible, ulna and facial bones) and restlessness.

Molecular pathology
Caffey disease is linked to a mutation of COL1A1.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

infantile cortical hyperostosis

Caffey disease An AD condition characterized by early onset hyperostosis and neo-osteogenesis, of facial and, less commonly, long bones, soft tissue swelling, hyperirritability, dysphagia, fever, pleuritis Lab ↑ ESR, alk phos
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


John Patrick, U.S. physician, radiologist, and pediatrician, the father of pediatric radiology, 1895-1978.
Caffey-Silverman syndrome - Synonym(s): Caffey syndrome
Caffey disease - Synonym(s): Caffey syndrome
Caffey syndrome - neonatal subperiosteal bone formation over many bones, especially the mandible and clavicles and the shafts of long bones. Synonym(s): Caffey disease; Caffey-Silverman syndrome; infantile cortical hyperostosis
Medical Eponyms © Farlex 2012
References in periodicals archive ?
A novel COLIA1 mutation in infantile cortical hyperostosis (Cafey disease) expands the spectrum of collagen-related disorders.
Familial infantile cortical hyperostosis: An update.
Case report 363: Infantile cortical hyperostosis (Caffey disease ICH) lilac bones, femora, tibiae and left fibula.
Infantile cortical hyperostosis (ICH), or Caffey's disease, is a rare entity of unknown origin that primarily affects infants.
Infantile cortical hyperostosis was introduced initially in the medical literature in 1939 by Roske(1) and in 1945 by Caffey and Silverman.(2) The disease primarily affects the bones, with monostotic or polyostotic bone compromise, and always includes inflammation.