Patient-specific induced pluripotent stem cells
as a model for familial dilated cardiomyopathy.
Chen, "Transplantation of induced pluripotent stem cells
without C-Myc attenuates retinal ischemia and reperfusion injury in rats," Experimental Eye Research, vol.
Oct3/4, Klf4, c-Myc and Sox2 produce induced pluripotent stem cells
. US8058065 B2.
Human iPS Cells: Human induced pluripotent stem cells
(iPSCs, cat# SC102A-1) were generated by transducing genetically unmodified human fibroblasts with viruses individually encoding the four human transcription factors (Oct4, Sox2, Klf4, and c-Myc) that have been shown to induce the reprogramming of somatic cells to a pluripotent state.
Park et al., "Generation of induced pluripotent stem cells
from human blood," Blood, vol.
Pluripotent cells fall into two groups, embryonic stem cells and induced pluripotent stem cells
. While embryonic stem cells come from human embryos, an ethically thorny issue, induced pluripotent stem cells
come from adult cells that are manipulated to be able to transform into any cell type.
They cover induced pluripotent stem-cell-derived cardiomyocytes (iPSC-CMs) as a novel diagnostic platform; preclinical large-animal models of cardiovascular regeneration; cell-free therapy with stem cell secretions: protection, repair, and regeneration of the injured myocardium; myoblasts as treatment for hereditary muscular dystrophies, cardiomyopathies, type 2 diabetes, solid tumors, and aging; stem cells in ophthalmology; stem cells for ocular therapies; cell therapy for liver regeneration; patient-specific induced pluripotent stem cells
for cardiac disease modeling; and the role of stem cells in evolution: a hypothesis.
There is another category called induced pluripotent stem cells
Plasticell, a biotechnology company specializing in stem cell screening and cell therapies, has entered into a collaboration with GlaxoSmithKline for the use of its stem cell screening technology, CombiCult, to optimize induced pluripotent stem cells
(iPSCs) to specific blood cell lineages for GSK's therapeutic research.
Induced pluripotent stem cells
(iPSCs) offer new opportunities in research application.
Throughout the years however, the spotlight has shifted towards a new type of stem cells; the induced pluripotent stem cells
The objective of this study was to create a 3D hydrogel system to culture and directly differentiate human induced pluripotent stem cells
(hiPSCs) into mature, synchronously contracting engineered cardiac tissues to mimic the native heart.