Nwojiji, "Potential risk of induced malaria
by blood transfusion in South-eastern Nigeria," McGill Journal of Medicine, vol.
Looking back for a view of the future: observations on immunity to induced malaria
. Am J Trop Med Hyg.
Herein, we induced malaria
by injecting P berghei ANKA in a susceptible strain of mice known to develop cerebral malaria-like symptoms and to present with 60-100% mortality within the second week following injection (for reviewsee ).
A large body of historical data exists from the deliberate laboratory infection of 2 populations: 1) patients receiving malariotherapy (intentionally induced malaria
) for neurosyphilis and related disorders; and 2) healthy prisoners who participated in malaria drug testing trials.
Simply injecting erythropoietin, a protein that naturally stimulates red blood cell synthesis, into infected mice also induced malaria
parasites to make more males.