indoleamine


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indoleamine

(ĭn′dō-lăm′ēn, ĭn′dō-lə-mēn′)
n.
Any of various naturally occurring analogs of indole, such as serotonin, containing an amine group.
References in periodicals archive ?
Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease.
Seropositive leprosy, indoleamine 2, 3-dioxygenase, anti-phenolic glycolipid-1 IgM.
Keywords: Dicolfenac sodium, tryptophan, kynurenine, indoleamine 2,3-dioxygenase, tryptophan 2,3-dioxygenase.
Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase.
Cancer cells use indoleamine 2,3-dioxygenase 1 (IDO1) pathway to suppress the host's immune response in order to facilitate survival, growth, invasion, and metastasis of malignant cells [13].
They also demonstrated that this tolerogenic effect was not mediated by indoleamine 2,3-dioxygenase expressing DCs.
Low level of ROS has been also shown to induce the immunoregulatory enzyme, indoleamine 2,3-dioxygenase, and enhance the function of Tregs [50].
More studies have shown that the immunosuppressive effects were associated with two mechanisms; first, soluble factors such as indoleamine 2,3 dioxygenase (IDO), prostaglandin E2 (PG E2), transforming growth factor beta (TGF-[beta]) and second, cell-cell contact (20-23).
Circulating endothelin-1 is increased in PE relative to normal pregnancy and indoleamine 2,3-dioxygenase, an enzyme that catabolizes tryptophan, is reduced, diminishing the inhibitory action of tryptophan depletion and resulting in immune cell activation.
The inflammatory mediators seem to activate the widespread tryptophane catabolizing enzyme indoleamine 2,3-deoxygenase (IDO) leading to decreased synthesis of 5-HT.
An additional antioxidant capacity of MEL is the ability of this indoleamine to promote the metabolism of toxic reactants to innocuous molecules.