IO Biotech's lead candidate, IO102, is an indolamine
2,3 dehydrogenase (IDO)-derived immune modulating therapy with dual mode of action killing both cancer and immune-suppressive cells.
Melatonin is an indolamine
secreted by the pineal gland during the dark phase of the daily light/dark cycle, it is synthesized from the tryptophan.
2,3-dioxygenase (IDO), first and rate-limiting enzyme of kynurenine (Kyn) pathway, is a tryptophan (Trp) degrading enzyme having immunoinflammatory effects.
Endotoxin-induced tryptophan degradation along the kynurenine pathway: The role of indolamine
2,3-dioxygenase and aryl hydrocarbon receptor-mediated immunosuppressive effects in endotoxin tolerance and cancer and its implications for immunoparalysis.
While most conventional antidepressant drugs for depression modulate brain monoamine and indolamine
activity (Nutt 2008) recent data suggest that the antidepressant effect of R.
Melatonin is an endogenous indolamine
, known to be a potent anti-inflammatory molecule but also a direct antioxidant [46,57,58].
MSCs' derived soluble factors, such as indolamine
2,3 * - dioxygenase (IDO), prostaglandin E2 (PGE2), 1.
Biochemically, both dopamine and norepinephrine are catecholamines, while serotonin is an indolamine
These mice also had moderate immunostaining for indolamine
2,3-dioxygenase (IDO), an immunoregulatory enzyme that modulates the production of IL-6 and IL-17.
and corticosteroid responses in mice bearing tumors.
hormone melatonin, secreted by the pineal gland, is widely acknowledged for its effects on sleep and circadian rhythm, and is used by many people as a sleep aid and to prevent jet lag.
We assessed different types of neuroactive compounds: the choline derivative acethylcholine, the indolamine
serotonin, and the catechols epinephrine, L-norephinephrine, dopamine, and L-DOPA.