indinavir


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Related to indinavir: nelfinavir, saquinavir

inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.

indinavir

/in·di·na·vir/ (in-di´nah-vir) an HIV protease inhibitor that causes formation of immature, noninfectious viral particles; used as the sulfate salt in the treatment of HIV infection and AIDS.

indinavir

(ĭn-dĭn′ə-vîr)
n.
A protease-inhibiting drug given in the form of its sulfate, used usually in combination with other drugs to suppress the replication of HIV.

indinavir

an antiretroviral protease inhibitor.
indications It is prescribed in the treatment of human immunodeficiency virus infection.
contraindications It should not be given to patients with a risk of kidney stones. It should be administered with other medications to reduce the risk of resistance development.
adverse effects Protease inhibitors increase plasma glucose, cholesterol, and triglyceride levels and cause a redistribution of body fat toward the center. Indinavir also can cause nephrolithiasis and hyperbilirubinemia.

indinavir

Crixivan®, MK-639 AIDS A potent HIV protease inhibitor used alone or with other antiretrovirals and nucleoside analogues for HIV Pts with ↓ CD4 cells Adverse effects ↑ LFTs, kidney stones, nausea, lipodystrophy–hyperglycemia, ↑ fats, ↑ waist, ↓ fat from face, arms, legs, ↑ BR. See AIDS, HIV, Protease inhibitor.

indinavir

A PROTEASE INHIBITOR drug used in combination with antiviral drugs to treat AIDS. The drug is on the WHO official list. A brand name is Crixivan.
References in periodicals archive ?
In this study, tacrolimus blood levels and AUC values of the groups which were pretreated with indinavir and ritonavir were found to be higher than the control group, whereas the values of ritonavir group were significant.
Venlafaxine has been shown to decrease indinavir concentrations in cellular models and healthy individuals in a controlled trial.
Recent research has demonstrated that a lower boosted indinavir dose (400/100mg) retains potency and is considerably less toxic.
That means indinavir and its protease inhibitor cousins are blocking GLUT4 but not GLUT1.
Key Findings: Mean steady-state indinavir Cmax was significantly reduced (20%) after seven days of vitamin C administration (10.
Interaction of sildenafil and indinavir when coadministered to HIV-positive patients.
Roy Gulick and a multicenter team report the longest patient follow-up to date showing that the simultaneous initiation of indinavir (Crixivan), zidovudine (Retrovir, AZT), and lamivudine (Epivir, 3TC) therapy is superior to sequential initiation (JAMA).
Changes to the clinical pharmacology section of the label note that trazodone--indicated for the treatment of depression--is a substrate of the cytochrome P450 3A4 (CYP3A4) enzyme and that trazodone metabolism can be inhibited by the CYP3A4 inhibitors ketoconazole, ritonavir, and indinavir.
High-performance liquid chromatographic assay to determine the plasma levels of HIV-protease inhibitors (amprenavir, indinavir, nelfnavir, ritonavir and saquinavir) and the non-nucleoside reverse transcriptase inhibitor (nevirapine) after liquid-liquid extraction.
Most include a protease inhibitor such as indinavir plus two reverse transcriptase inhibitors such as zidovudine and lamivudine.
For example, the FDA issued a warning that Saint-John's-wort decreases the effectiveness of HIV drugs, such as indinavir," points out Larry Augsburger, a professor at the University of Maryland School of Pharmacy and past president of the American Association of Pharmaceutical Scientists.
More deadly examples of interactions mediated by PXR have also been described, including breakdown of the immunosuppressant cyclosporin and the anti-HIV drug Indinavir.