Hospital transmission of MERS-CoV has been attributed to the suboptimal infection control practices such as lack of personal protective equipment use, poor hand hygiene, delay in timely index case
isolation, lack of negative pressure rooms, and performing aerosolising procedures without appropriate personal protective equipment.
Moreover, estimates of the serial interval (i.e., time between index case
and symptom onset in secondary infection) are limited to pandemic influenza in nonhousehold settings (6,12-15).
This study was conducted among household contacts of index cases
with sputum smear-positive PTB in 13 selected PHCs from 1 August 2015 to 29 February 2016.
Forty-one pediatric index cases
and 114 family members were included in this study.
From the remaining 109 living relatives, 64 (including 4 index cases
) elected to enroll in the study and underwent complement testing.
We are thankful to the Faculty of Pediatrics of LUMHS and Chest specialists of Kori Institute of Chest Diseases for allowing us to collect data and provision of diagnostic and management facilities to the index cases
and clinical suspects of our study.
The index cases
had normal platelet count and leucocytic count highlighting that there was neither bone marrow suppression nor hypersplenism.
Among 15 Ebola outbreaks in remote areas of nine counties with index case
symptom onset dates during July 16--November 20, 2014, 12 investigations had complete data (Figure 1).
Among the 71 index cases
47 (66-2%) were male and 16 (22-5%) were children (age below 15 years).
a--anthropometric parameters: weight and size of the index case
Since Figure 1 does not show effect separately for the clinical form of the index cases
, cases and person-time of all control and experimental groups could be combined to a single rate for chemoprophylaxis and for control groups.
This analysis included 6831 contacts of 1319 index cases
with an average of 5 (SD = 4.1) contacts per index case