indapamide


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indapamide

 [in-dap´ah-mīd]
a thiazide diuretic used in treatment of edema, such as in congestive heart failure or liver disease, as well as of hypertension.

indapamide

Apo-Indapamide (CA), Dom-Indapamide (CA), Gen-Indapamide (CA), Lozide (CA), Lozol, Natrilix (UK), Nindaxa (UK), Novo-Indapamide (CA), Nu-Indapamide (CA), PHL-Indapamide (CA), PMS-Indapamide (CA), Riva-Indapamide (CA)

Pharmacologic class: Thiazide-like diuretic

Therapeutic class: Diuretic, antihypertensive

Pregnancy risk category B

Action

Increases sodium and water excretion by inhibiting sodium reabsorption in distal tubule; enhances excretion of sodium, chloride, potassium, and water. May cause arteriolar vasodilation.

Availability

Tablets: 1.25 mg, 2.5 mg

Indications and dosages

Edema caused by heart failure

Adults: 2.5 mg P.O. daily in morning. After 1 week, may increase to 5 mg/day.

Mild to moderate hypertension

Adults: 1.25 mg P.O. daily in morning. May increase q 4 weeks, up to 5 mg/day.

Contraindications

• Hypersensitivity to drug, other thiazide-like drugs, or tartrazine
• Anuria

Precautions

Use cautiously in:
• renal or severe hepatic impairment, ascites, fluid or electrolyte imbalances, gout, systemic lupus erythematosus, impaired glucose tolerance, hyperparathyroidism, bipolar disorder
• pregnant or breastfeeding patients.

Administration

• Administer with food or milk to reduce GI upset.
• Give early in day to avoid nocturia.

Adverse reactions

CNS: dizziness, light-headedness, headache, restlessness, insomnia, lethargy, fatigue, drowsiness, asthenia, depression, anxiety, nervousness, paresthesia, irritability, agitation

CV: orthostatic hypotension, palpitations, premature ventricular contractions, arrhythmias

EENT: blurred vision, rhinorrhea

GI: nausea, vomiting, diarrhea, constipation, bloating, epigastric distress, gastric irritation, abdominal pain or cramps, dry mouth, anorexia

GU: nocturia, polyuria, glycosuria, erectile dysfunction

Metabolic: dehydration, gout, hyperglycemia, hypokalemia, hypocalcemia, hypomagnesemia, hyponatremia, hypovolemia, hypophosphatemia, hyperuricemia, hypochloremic alkalosis

Musculoskeletal: muscle cramps and spasms

Skin: flushing, rash, urticaria, pruritus, photosensitivity, cutaneous vasculitis, necrotizing vasculitis

Other: weight loss

Interactions

Drug-drug.Amphotericin B, corticosteroids: additive hypokalemia

Antihypertensives, nitrates: additive hypotension

Cholestyramine, colestipol: decreased indapamide absorption

Lithium: decreased lithium excretion, increased risk of lithium toxicity

Sulfonylureas: decreased hypoglycemic efficacy

Drug-diagnostic tests.Bilirubin, blood and urine glucose (in diabetic patients), blood urea nitrogen (BUN), calcium, creatinine, uric acid: increased values Cholesterol, low-density lipoproteins, magnesium, potassium, protein-bound iodine, sodium, triglycerides, urinary calcium: decreased values

Drug-herbs.Ginkgo: decreased antihypertensive effect

Licorice, stimulant laxative herbs (aloe, cascara sagrada, senna): increased risk of hypokalemia

Drug-behaviors.Acute alcohol ingestion: additive hypotension

Sun exposure: increased risk of photosensitivity

Patient monitoring

Assess for signs and symptoms of hypokalemia, including ventricular arrhythmias, muscle weakness, and cramping.
• Monitor BUN, creatinine, and electrolyte levels.
• Assess daily weight and fluid intake and output.
• Monitor blood pressure response to drug.
• Watch for signs and symptoms of orthostatic hypotension.

Patient teaching

• Advise patient to consume potassium-rich foods, such as oranges, bananas, potatoes, and spinach.
• Instruct patient to move slowly when sitting up or standing, to avoid dizziness from sudden blood pressure decrease.
• Tell patient to weigh himself daily on same scale at same time of day while wearing similar clothing. Instruct him to report gain of more than 2 lb (0.9 kg) in 1 day or 5 lb (2.2 kg) in 1 week.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

indapamide

/in·dap·amide/ (in-dap´ah-mīd) an antihypertensive and diuretic with actions and uses similar to those of chlorothiazide.

indapamide

(ĭn-dăp′ə-mīd′)
n.
A diuretic that inhibits the reabsorption of sodium and chloride by the kidneys, used to treat high blood pressure and edema.

indapamide

A diuretic drug used to treat high blood pressure (HYPERTENSION). Brand names are Natramid and Natrilix.

indapamide (indap´əmīd´),

n brand name: Lozol;
drug class: diuretic, thiazide-like; action: acts on distal tubule by increasing excretion of water, sodium, chloride, potassium;
uses: edema, hypertension.
References in periodicals archive ?
During the study's 4 years of active treatment, patients randomized to receive the perindopril and indapamide combination had significantly reduced blood pressure, compared with the control patients.
24] At least one study (n = 20) suggests the use of indapamide for partial neurogenic DI, [23] but this drug requires more studies for confirmation.
She had a history of hypertension for nine years and had been treated with indapamide for the last two years.
The first part of ADVANCE investigated the effects of intensive blood pressure lowering on outcome using a fixed combination of perindopril and indapamide (Preterax(R)).
In the HYVET trial, patients were randomized to placebo or indapamide SR 1.
The ADVANCE trial, run at 215 centers in 20 countries, was sponsored in part by Servier, which markets a formulation of perindopril and indapamide (Preterax).
In the meantime, study participants who were on the trial medication will have the option to switch to active indapamide 1.
The recent approvals of diclofenac, diflunisal, and indapamide have the potential to help improve its earnings while it digests the new acquisitions and completes its management reorganization.
Tenders are invited for Amlodipine 5Mg Plus Indapamide 1.
BERLIN, June 16 /PRNewswire/ -- New results of the ADVANCE (Action in Diabetes and Vascular disease: PreterAx and DiamicroN-MR Controlled Evaluation) trial have been presented today at the European Society of Hypertension (ESH) and show that the antihypertensive Preterax - a fixed combination of the ACE-inhibitor perindopril and the diuretic indapamide - reduces the likelihood of new or worsening nephropathy (kidney damage) in patients with type 2 diabetes mellitus by up to 31% and in patients with existing kidney damage leads to nephropathy regression in about one-in-six.