incretin


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Related to incretin: Sitagliptin

in·cre·tin

(in-krē'tin),
Generic term for all insulinotropic substances originating in the gastrointestinal tract that are released into the circulation by meals containing glucose. One is glucose-dependent insulinotropic polypeptide, which is released into the circulation from crypt cells in the proximal duodenum and jejunum after meals containing glucose or long-chain fatty acids. Another is proglucagon-derived polypeptide, cleavage product of glucagon, which is further processed into glucagonlike peptide-1 and then to glucagonlike insulinotropic peptide.
Farlex Partner Medical Dictionary © Farlex 2012

incretin

(ĭn-krēt′n)
n.
Any of several gastrointestinal hormones that bring about the release of insulin from the pancreas after carbohydrate ingestion and are essential in maintaining normal levels of glucose in the blood.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

in·cre·tin

(in-krē'tin)
Generic term for all insulinotropic substances originating in the gastrointestinal tract that are released into the circulation by meals containing glucose. One is the glucose-dependent insulinotropic polypeptide, which is released into the circulation from crypt cells in the proximal duodenum and jejunum after meals containing glucose or long-chain fatty acids. Another is proglucagon-derived polypeptide, a cleavage product of glucagon, which is further processed into glucagonlike peptide-1 and then to glucagonlike insulinotropic peptide.
Compare: bioregulator
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

in·cre·tin

(in-krē'tin)
Generic term for all insulinotropic substances originating in the gastrointestinal tract.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Drucker's diabetes research has focused on a group of hormones called incretins, which help the pancreas produce insulin to use the energy it receives from food.
Newer antidiabetic medications like incretin mimetics, SGLT-2 inhibitors, newer basal and prandial insulins, Continuous subcutaneous insulin infusion can significantly reduce GV.
"One way that gastric bypass might work is that it alters the incretins that drive insulin secretion and sensitivity," Dr.
Key players are insulin, glucagon, amylin, incretins, and even the bacterial population of the gut.
A previous study on dog fetus cell culture found that production of nitric oxide (NO) increased due to the incretin GIP, which in turn resulted in increased portal venous flow (5).
(i) enteric hormonal modulation and the incretin theory,
The incretin (INtestinal seCRETion of INsulin) system comprises two key hormones: glucagon like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which act to augment insulin biosynthesis and secretion, suppress glucagon secretion, inhibit gastric emptying, and reduce appetite [87].
Gastric emptying and glycemic variations are interdependent processes influenced by the incretin system, the solid or liquid state of ingested nourishment, and the macronutrient composition of food [1-3].
DPP4 destroys the hormone incretin that stimulates insulin secretion in response to meals.
Observations that oral glucose provokes a greater insulin secretory response than the same amount of glucose injected into a vein, (1) coupled with isolation of an extract from the upper intestine that produces a fall in blood glucose, (2,3) led to recognition that the incretin system plays a role in glucose homeostasis.