inclusion body

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inclusion body

n.
An abnormal structure in a cell nucleus or cytoplasm having characteristic staining properties and usually composed of protein, occurring primarily in infectious diseases, especially viral infections such as rabies.

inclusion body

A generic term for a circumscribed mass of intracellular or intranuclear material, which is often “foreign” to the cell or nucleus.

Examples
Metal (e.g., lead, mercury); viral particles (e.g., herpes, CMV); metabolically inactive materials (e.g., ceroid, Mallory bodies).

inclusion body

  1. a body present in the nuclei or cytoplasm of cells infected by viruses or other intracellular parasites.
  2. an insoluble protein aggregate that may form a crystalline structure inside host cells. An inclusion body may form as a result of overproduction of recombinant or normal protein in an overexpression system (see GENE EXPRESSION).

inclusion body

round, oval or irregular-shaped bodies in the cytoplasm and nucleus of cells, as in diseases due to viral infection, such as rabies, inclusion body rhinitis. May be acid-fast as in lead poisoning. See also bollinger bodies, borrel bodies, elementary body (1), guarnieri bodies, joest bodies, Negri body, paschen bodies and type A, type B inclusion bodies (below).

falcon inclusion body disease
caused by a herpesvirus, the clinical signs include weakness, anorexia, diarrhea and a mortality rate of 100%. There is a profound leukopenia.
inclusion body hepatitis
a disease of young chickens caused by an adenovirus and characterized by jaundice and anemia. The mortality rate is about 25%. Called also chicken hemorrhagic syndrome.
inclusion body rhinitis
a disease of the upper respiratory tract of young pigs caused by a cytomegalovirus. Clinically there is paroxysmal sneezing, a serous, ocular and nasal discharge, and a benign course. It may be a precursor to atrophic rhinitis.
snake inclusion body disease
thought due to a virus; observed in many boid snakes; characterized by heavy mortality after signs of CNS disease; inclusion bodies in most tissues, especially brain.
type A inclusion body
found in chromatically disrupted nuclei with margination of the chromatin fragments and the inclusion body is amorphous or granular and acid-staining; characteristic of cells infected with, for example, herpesvirus and adenovirus.
type B inclusion body
the nucleus is still well organized, there is no margination of chromatin and the inclusion bodies are well defined; seen in cells infected with, for example, distemper virus.