inclusion body


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Related to inclusion body: inclusion body disease

inclusion body

n.
An abnormal structure in a cell nucleus or cytoplasm having characteristic staining properties and usually composed of protein, occurring primarily in infectious diseases, especially viral infections such as rabies.

inclusion body

A generic term for a circumscribed mass of intracellular or intranuclear material, which is often “foreign” to the cell or nucleus.

Examples
Metal (e.g., lead, mercury); viral particles (e.g., herpes, CMV); metabolically inactive materials (e.g., ceroid, Mallory bodies).

inclusion body

  1. a body present in the nuclei or cytoplasm of cells infected by viruses or other intracellular parasites.
  2. an insoluble protein aggregate that may form a crystalline structure inside host cells. An inclusion body may form as a result of overproduction of recombinant or normal protein in an overexpression system (see GENE EXPRESSION).

inclusion body

extraneous (e.g. viral) material within cell cytoplasm or nucleus

inclusion body

round, oval or irregular-shaped bodies in the cytoplasm and nucleus of cells, as in diseases due to viral infection, such as rabies, inclusion body rhinitis. May be acid-fast as in lead poisoning. See also bollinger bodies, borrel bodies, elementary body (1), guarnieri bodies, joest bodies, Negri body, paschen bodies and type A, type B inclusion bodies (below).

falcon inclusion body disease
caused by a herpesvirus, the clinical signs include weakness, anorexia, diarrhea and a mortality rate of 100%. There is a profound leukopenia.
inclusion body hepatitis
a disease of young chickens caused by an adenovirus and characterized by jaundice and anemia. The mortality rate is about 25%. Called also chicken hemorrhagic syndrome.
inclusion body rhinitis
a disease of the upper respiratory tract of young pigs caused by a cytomegalovirus. Clinically there is paroxysmal sneezing, a serous, ocular and nasal discharge, and a benign course. It may be a precursor to atrophic rhinitis.
snake inclusion body disease
thought due to a virus; observed in many boid snakes; characterized by heavy mortality after signs of CNS disease; inclusion bodies in most tissues, especially brain.
type A inclusion body
found in chromatically disrupted nuclei with margination of the chromatin fragments and the inclusion body is amorphous or granular and acid-staining; characteristic of cells infected with, for example, herpesvirus and adenovirus.
type B inclusion body
the nucleus is still well organized, there is no margination of chromatin and the inclusion bodies are well defined; seen in cells infected with, for example, distemper virus.
References in periodicals archive ?
Reproduction of hydropericardium syndrome in three-week-old cyclophosphamide treated specific pathogen free chickens by adenoviruses from inclusion body hepatitis.
Amyloid-beta deposition in skeletal muscle of transgenic mice: possible model of inclusion body myopathy.
And although the viruses were found in snakes with inclusion body disease, that doesn't necessarily mean the virus causes the illness.
The main component of the protein in the inclusion body has an approximate molecular weight of 27 kD (118) or 32 kD (119), that is rich in glutamate and aspartate and contained about 40 to 50 [micro]g lead per milligram of protein.
Inclusion Body Myositis causes a gradual deterioration of muscle strength and can affect most limb muscles.
Instead, they found that inclusion body formation predicts neuronal survival.
After centrifugation, the supernatant was discarded; the inclusion body pellet was washed briefly in PBS, then reconstituted in 2.
Analysis of the samples taken 5 h after the addition of IPTG clearly shows that recombinant protein expression is induced by IPTG, and that the recombinant protein is produced predominantly in the insoluble inclusion body fraction (Fig.
The project began last summer when a man with rare muscle disease called inclusion body myositis--which left him unable to grasp or lift even small objects--sought care from the Volunteers for Medical Engineering (VME) group, Baltimore.
Diseases affecting muscles include polymyositis, dermatomyositis and inclusion body myositis.
They are contrasted with other types of inflammatory myopathies, including inclusion body myositis and myositis caused by infection or drug reactions.