inclusion bodies


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in·clu·sion bod·ies

distinctive structures frequently formed in the nucleus or cytoplasm (occasionally in both locations) in cells infected with certain filtrable viruses; may be demonstrated by means of various stains, especially Mann eosin methylene blue or Giemsa techniques and visible by light microscopy. Nuclear inclusion bodies are usually acidophilic and are of two morphologic types: 1) granular, hyaline, or amorphous bodies of various sizes, that is, Cowdry type A inclusion bodies, occurring in such diseases as herpes simplex infection or yellow fever; 2) more circumscribed bodies, frequently with several in the same nucleus (and no reaction in adjacent tissue), that is, the type B bodies, occurring in such diseases as Rift Valley fever and poliomyelitis. Cytoplasmic inclusion bodies may be: 1) acidophilic, relatively large, spheric or ovoid, and somewhat granular, as in variola or vaccinia, rabies, and molluscum contagiosum; 2) basophilic, relatively large, complex combinations of viral and cellular material, as in trachoma, psittacosis, and lymphogranuloma venereum. In some instances, inclusion bodies are known to be infective and probably represent aggregates of virus particles in combination with cellular material, whereas others are apparently not infective and may represent only abnormal products formed by the cell in response to injury.

in·clu·sion bod·ies

(in-klū'zhŭn bod'ēz)
Distinctive structures frequently formed in the nucleus or cytoplasm (occasionally in both locations) in cells infected with various filterable viruses; observed especially in nerve, epithelial, or endothelial cells.

inclusion bodies

Microscopically visible masses of virus material, or areas of altered staining behaviour, seen within cells in a number of virus infections such as RABIES, herpes infections, papovavirus infections and adenovirus infections.
References in periodicals archive ?
Skin punch biopsy specimen (D) showing leukocyte infiltration and cytoplasmic inclusion bodies (arrows) (hematoxylin and eosin stain, original magnification * 60).
Caption: Figure 2: Histocytology stain showing CMV inclusion bodies from elbow biopsy.
The inclusion bodies have been reported to stain best with Masson trichrome and appear bright red against a blue background (Figure 5).
TEM observations showed that the derivative virions of the inclusion bodies were rod-shaped and scattered within the inclusion bodies with an irregular arrangement.
Histopathological changes, including inclusion bodies, cell fragmentation, and central core lesions, were observed in the muscles of the animals that were immobilized and then rehabilitated using stretching (Table 1 and Figure 1).
[6] when he found a macrophagic infiltrate with PAS positive intracytoplasmic inclusion bodies in the urinary bladder of a 66-years-old man who died of pulmonary tuberculosis.
The changes observed during histopathology of livers of birds in other group included the presence of intra-nuclear inclusion bodies, degenerative changes, infiltration of heterophils, lymphocytes necrosis and atrophy.
In addition, histological analysis of the lesioned epidermal tissue typically reveals epidermal hyperplasia and epidermal fibroblast proliferation as well as the development of eosinophilic intracytoplasmic inclusion bodies (O'Connor et al.
Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells
More commonly used in manufacturing, bacterial cells produce inclusion bodies or intracellular, soluble protein.