In addition, some members of the Solanaceae family, which include tobacco, contain chemical(s) that were amongst the strongest inactivators of nNOS.
By analysis of 33 plant extracts, we found 18 plants with inactivators of nNOS.
Whatever the reason for the existence of a plant-derived inactivator(s) of NOS, this discovery provides an opportunity to identify potential novel inactivators and regulators of NOS for pharmacological and biological use.
This, in turn, may help elucidate the structure of the chemical(s), as well as provide a source of a potentially novel inactivator of nNOS.
The residue was reconstituted in 0.5 ml of water and tested for the presence of the nNOS inactivator. This material was compared to the original solution of tobacco extract.
"Recent studies have shown that all third generation aromatase inhibitors or inactivators
increase bone resorption," the investigators said, adding that they are conducting a substudy to assess bone mineral loss.
The bNAbs and HIV entry inhibitors or inactivators are the best candidates.
This protein is also considered an HIV protein inactivator because it was proved to inactivate free HIV virions.
Ribosomal inactivation can also alter ER functions, and some chemical ribosomal inactivators
such as trichothecenes, verotoxins, or ricin enhance unfolded protein responses that contribute to proinflammatory cytokine production and apoptosis-linked tissue injuries [54-56].
Although more specific inhibitors and inactivators
of SAHase have been tested, among them 2-chloroadenosine, aristeromycin, eritadenine, adenosine dialdehyde, and adenine arabinofuranoside , they either competed with the anti-SAH antibody or failed to inactivate the enzyme completely within acceptable incubation times or concentrations (data not shown).