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n a substance added to a culture medium to prevent the activity of an inoculant. Penicillinase is added to the culture medium to prevent the activity of penicillin that might be carried over from a root canal treatment.
References in periodicals archive ?
Fractions were collected from the flow-through and tested for the presence of the inactivator.
Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase.
Europe is the largest market for Mycotoxin Inactivators, whereas Poultry feed is the biggest and the fastest growing segment.
Mauri D, Pavlidis N, Polyzos NP, et al: Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: Meta-analysis.
The steroidal inactivators exemestane and formestane inhibited aromatase activity at all concentrations tested.
Aromatase inhibitors and inactivators are known to decrease estradiol levels.
By demonstrating that chemically unreactive groups linked to an appropriate affinity group can be employed in the design of potent and selective inactivators of powerfully nucleophilic cysteine proteinases, the concept of affinity labels was extended beyond the notion of reactive biochemical and pharmacological reagents to include compounds which now hold forth the possibility of practical clinical endpoints.
It has only recently been appreciated that reactive oxygen intermediates have broad potential to act as secretagogues, enzyme activators (17-20) and regulators of transcription along with their more familiar roles as enzyme inactivators, antiseptics, cytotoxins, and mutagens (17-20).
It is the first and only oral drug in a class of aromatase inactivators.
Enzyme Reaction Mechanisms; Reversible Modes of Inhibitor Interactions with Enzymes; Assay Considerations for Compound Library Screening; Lead Optimization and Structure-Activity Relationships for Reversible Inhibitors; Slow Binding Inhibitors; Tight Binding Inhibitors; and Irreversible Enzyme Inactivators.
AROMASIN, currently approved for the treatment of advanced breast cancer in postmenopausal women failing tamoxifen, is the first and only oral drug in a new class of therapies called aromatase inactivators.
Although more specific inhibitors and inactivators of SAHase have been tested, among them 2-chloroadenosine, aristeromycin, eritadenine, adenosine dialdehyde, and adenine arabinofuranoside [14], they either competed with the anti-SAH antibody or failed to inactivate the enzyme completely within acceptable incubation times or concentrations (data not shown).