inactivated


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.
Related to inactivated: inactivated vaccine

poliovirus vaccine, inactivated

Creutzfeldt-Jakob disease

Spastic pseuodoparalysis, subacute spongiform encephalopathy Neurology An invariably fatal, kuru-like infection which causes a form of presenile dementia primarily affecting middle-aged adults, caused by an aberrant protein, a prion Clinical 2-4 yrs after exposure → pyramidal tract disease with Babinski sign, nervousness, loss of facial expression; cerebellar dysfunction with ataxia, myoclonus, unsteady gait; basal ganglia involvement is manifest by rigidity, bradykinesia, intention tremor, dystonic postures, choreoathetosis, muscle spasms, imbalance, dementia Prognosis No treatment, no cure; CJD progresses rapidly to coma and death in 3 to 12 months. See Bovine spongiform encephalopathy, Kuru, Prion, Scrapie.
Creutzfeld-Jakob disease agent–disinfection
Inactivated by autoclaving for 1 hour at 132ºC and 20 psi, 5% hypochlorite, and 0.03% permanganate solutions. Instruments 0.1 N sodium hydroxide for 2 hours; 5% bleach–NaOCl for 4 hours; all surfaces should be scrubbed with iodine or phenol-based detergents
NOT inactivated by boiling, 10% formalin, 70% alcohol, UV light  

inactivated

rendered inactive; the activity is destroyed.

inactivated viruses
treated so that they are no longer able to produce evidence of growth or damaging effect on tissue. Inactivation may be by physical means including heat, ultraviolet light, ultrasonic vibration, or by chemical treatment. Used in inactivated viral vaccines.
References in periodicals archive ?
Major Finding: In a simulation model that projected influenza-related outcomes for a hypothetical cohort of children, cost-effectiveness ratios for the live attenuated vaccine were $20,000-$33,000 per quality-adjusted life year and those for the inactivated vaccine were $21,000-$37,000 per QALY.
As originators of inactivated flour, back in 1963, Bowmans see this development at Whitley Bridge as a logical extension of their comprehensive Trident product range, which complements existing capacity at their Ickleford mill at Hitchen in Hertfordshire.
Specimens that have not been inactivated must still be treated as potentially infectious after electron microscopic examination.
In a randomized, controlled trial of 791 children who were less than 16 years old, both cold-adapted and inactivated vaccines were effective against both H1N1 and H3N2 viruses.
Normally, genes are individually activated or inactivated by proteins targeted to the specific genes.
That threat will continue until injections of inactivated vaccine fully replace live, oral vaccines, he says.
2: delivery of trivalent inactivated polio vaccine with the international non-proprietary name poliomyelitis vaccine (inactivated) ".
2], using RPMI-1640 medium supplemented with 10% heat-inactivated horse serum, 5% inactivated fetal bovine serum, and 25 [micro]g/mL penicillin--streptomycin (all from Gibco, Grand Island, NY).
Inactivated 1 January 1938 at Harrisburg, Pennsylvania; concurrently withdrawn from the Organized Reserves and allotted to the Regular Army.
During this process, the scientists were able to procure hybrids containing either the normal human X chromosome or its inactivated counterpart.
Heating each sample for 6 minutes in a microwave oven inactivated 30 to 40 percent of the [B.
Our robust processes, which include four separate viral reduction steps, demonstrate that significant levels of pathogens can be removed or inactivated in the highly unlikely event that they are present in pools of plasma prior to manufacture.