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Related to inactivated: inactivated vaccine
Creutzfeldt-Jakob diseaseSpastic pseuodoparalysis, subacute spongiform encephalopathy Neurology An invariably fatal, kuru-like infection which causes a form of presenile dementia primarily affecting middle-aged adults, caused by an aberrant protein, a prion Clinical 2-4 yrs after exposure → pyramidal tract disease with Babinski sign, nervousness, loss of facial expression; cerebellar dysfunction with ataxia, myoclonus, unsteady gait; basal ganglia involvement is manifest by rigidity, bradykinesia, intention tremor, dystonic postures, choreoathetosis, muscle spasms, imbalance, dementia Prognosis No treatment, no cure; CJD progresses rapidly to coma and death in 3 to 12 months. See Bovine spongiform encephalopathy, Kuru, Prion, Scrapie.
Creutzfeld-Jakob disease agent–disinfection
Inactivated by autoclaving for 1 hour at 132ºC and 20 psi, 5% hypochlorite, and 0.03% permanganate solutions. Instruments 0.1 N sodium hydroxide for 2 hours; 5% bleach–NaOCl for 4 hours; all surfaces should be scrubbed with iodine or phenol-based detergents
NOT inactivated by boiling, 10% formalin, 70% alcohol, UV light