Because of the extreme pressure stability of some food-quality enzymes, it might be necessary to use combined processes (pressure and temperature) to inactivate
enzymes at industrially relevant pressures.
Abstract #317 discusses the use of the INTERCEPT platelet system to inactivate
pathogens in donor platelets during a recent epidemic of the Chikungunya virus.
Anergen, headquartered in Redwood City, is developing therapies for the treatment of autoimmune diseases using proprietary biopharmaceutical compounds that are designed to inactivate
or anergize the specific T cells in the immune system responsible for each disease.
During last week's ISBT congress in Cape Town, South Africa, Cerus presented data (Abstract 5PS-3402) from ongoing studies on the INTERCEPT system's ability to inactivate
pathogens in red blood cells using its modified S-303 treatment process.
Studies on the INTERCEPT system's inactivation of emerging pathogens include inactivation of an emerging West Nile Virus strain in South France (Abstract P-367) and the INTERCEPT system's ability to inactivate
Trypanosome cruzi, or Chagas disease, which has been transmitted via platelet transfusions in at least six cases in the United States and Canada (Abstract P-368).
In the 1960s, geneticists discovered that female mammalian embryos randomly inactivate
one of their X chromosomes.
Until now, scientists had to 'fix' or inactivate
such nanoparticles to see below the 200 nm threshold using electron microscopy, which precluded observing real-time processes.
To thwart this death spiral, infectious disease specialists and biotechnology and pharmaceutical companies are working to develop compounds to sop up or inactivate
bits of partially destroyed bacteria that can keep the body battling and already eradicated infection.
Making matters more complicated, a single imprinting gene may inactivate
several different genes, including a wide variety of cancer-suppressor genes, says Sapienza.
It means that if one is to make a vaccine, you have to inactivate
the function of the envelope protein that kills the cells," says Garry.
The system inactivates
plasma and platelets using the same illumination device, process and active compound.
In the test tube, bergamottin inactivates
cytochrome P450 3A4, a digestive enzyme that metabolizes many drugs, ranging from antihistamines to medications for high blood pressure (SN: 5/24/97, p.