in vivo mutagenesis

in vivo mutagenesis

MUTAGENESIS occurring inside living CELLS. Generally the MUTATIONS are induced randomly However, there are techniques that permit mutations to be directed to certain regions of the GENOME.
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The analysis examined data from two contradictory studies on rates of mutation at the HPRT locus (a measure of in vivo mutagenesis) in newborn cord blood samples.
"Once [the cassette] is created," Resnick adds, "you have the opportunity to do any number of changes in the region--hundreds of specific changes and many random changes within a week." He says the technique is accurate about 80% of the time, which is as efficient and accurate as standard in vivo mutagenesis systems, and the accuracy can be checked relatively easily.