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The analysis examined data from two contradictory studies on rates of mutation at the HPRT locus (a measure of in vivo mutagenesis) in newborn cord blood samples.
"Once [the cassette] is created," Resnick adds, "you have the opportunity to do any number of changes in the region--hundreds of specific changes and many random changes within a week." He says the technique is accurate about 80% of the time, which is as efficient and accurate as standard in vivo mutagenesis systems, and the accuracy can be checked relatively easily.
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